Adoptive immunotherapy shows encouraging benefit on non-small cell lung cancer: a systematic review and meta-analysis

Binghao Zhao, Wenxiong Zhang _, Dongliang Yu, Jianjun Xu and Yiping Wei

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Oncotarget. 2017; 8:113105-113119. https://doi.org/10.18632/oncotarget.19373

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Binghao Zhao1, Wenxiong Zhang1, Dongliang Yu1, Jianjun Xu1 and Yiping Wei1

1Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China

Correspondence to:

Wenxiong Zhang, email: [email protected]

Keywords: non-small cell lung cancer, adoptive immunotherapy, meta-analysis

Received: April 25, 2017     Accepted: July 06, 2017     Published: July 19, 2017


Although adoptive immunotherapy (AIT) is a novel emerging target treatment for non-small cell lung cancer (NSCLC), its actual efficacy remains controversial. In this meta-analysis, we aimed to evaluate the efficacy of AIT for NSCLC. We systematically searched PubMed, the Cochrane Library, EMBASE, Medline, and Web of Science for relevant parallel randomized controlled trials (RCTs) and high-quality observation studies of AIT without any language restrictions. Two investigators reviewed all the texts and extracted information regarding overall survival rate (OS), progression-free survival rate (PFS), objective response rate (ORR), and disease control rate (DCR) from eligible studies; sensitivity analyses and subgroup analyses were also conducted to reduce heterogeneity

Of 319 suitable studies, 15 studies (13 RCTs and 2 observation studies) involving 1684 patients were finally included. Compared to the Control therapy (CT) group, the AIT group exhibited better 1-year OS (P = 0.001), 2-year OS (P < 0.001), 3-year OS (P < 0.001), 5-year OS (P = 0.032), 1-year PFS (P < 0.001), and 2-year PFS (P = 0.029). The difference in the ORR (P = 0.293) and DCR (P = 0.123) was not significant between the groups. The subgroup analysis showed that DC/CIK did more benefit to NSCLC patients than LAK and the cycles not associated with AIT efficacy.

AIT can significantly improve the OS and PFS with acceptable toxicity for NSCLC. Nevertheless, further multicenter studies are needed to confirm our conclusion and determine which adoptive immunotherapy is associated with the greatest efficacy.

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