Oncotarget

Clinical Research Papers:

Reassessment of different criteria for diagnosing post-hepatectomy liver failure: a single-center study of 1683 hepatectomy

Yongchang Zheng, Huayu Yang, Li He, Yilei Mao _, Hanze Zhang, Haitao Zhao, Shunda Du, Yiyao Xu, Tianyi Chi, Haifeng Xu, Xin Lu, Xinting Sang and Shouxian Zhong

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Oncotarget. 2017; 8:89269-89277. https://doi.org/10.18632/oncotarget.19360

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Abstract

Yongchang Zheng1,*, Huayu Yang1,*, Li He2,*, Yilei Mao1, Hanze Zhang3, Haitao Zhao1, Shunda Du1, Yiyao Xu1, Tianyi Chi1, Haifeng Xu1, Xin Lu1, Xinting Sang1 and Shouxian Zhong1

1 Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China

2 Department of Ophthalmology, School of Medicine, Emory University, Atlanta, Georgia, USA

3 Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, Florida, USA

* These authors have contributed equally to this work

Correspondence to:

Yilei Mao, email:

Keywords: PHLF, ISGLS, child-pugh score, “50-50” criteria, Clavien-Dindo

Received: April 18, 2017 Accepted: June 20, 2017 Published: July 18, 2017

Abstract

Assessing the incidence and severity of post-hepatectomy liver failure (PHLF) can be based on different criteria, and we wished to compare the diagnostic efficiency and specificity of different PHLF criteria. Data from patients (n=1683) who received hepatectomies in the liver surgery department of Peking Union Medical College Hospital from April 2008 to August 2014 were retrospectively analyzed. Possible PHLF patients were screened according to the criteria of the International Study Group of Liver Surgery (ISGLS). Subsequently, other PHLF evaluation methods, including Child-Pugh score, “50-50” criteria, Model for End-Stage Liver Disease (MELD) score, and Clavien-Dindo classification were used to assess the suspected PHLF patients, and statistical analysis was performed for correlation of these methods with clinical prognoses. Using ISGLS grading, 40 cases (2.38%) were suspected to have PHLF, among whom 5 (0.30%) patients died. Of the 40 cases there were 9 patients of ISGLS grade A, 21 of grade B, and 10 of grade C. Among the entire group, Child-Pugh scoring showed 3 patients in grade A, 35 in grade B, and 2 in grade C, while only 5 patients met the “50-50” criteria. Interestingly, MELD scores ≥11 points were found only in 3 cases. Twenty-eight patients were classified as Clavien-Dindo grade I, 8 as grade II, 3 as grade III, and 1 as grade IV. Prothrombin time on postoperative day 5 (PT5), ISGLS, and Clavien-Dindo were found to have significant correlation with the prognosis of PHLF (r>0.5, p <0.05), thus can be used as prognosis predictors for PHLF patients.


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