Oncotarget

Clinical Research Papers:

Mid-arm muscle circumference as a surrogate in predicting insulin resistance in non-obese elderly individuals

Yuan-Ping Chao, Yi-Fen Lai, Tung-Wei Kao, Tao-Chun Peng, Yuan-Yung Lin, Mu-Tsun Shih, Wei-Liang Chen and Li-Wei Wu _

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Oncotarget. 2017; 8:79775-79784. https://doi.org/10.18632/oncotarget.19340

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Abstract

Yuan-Ping Chao1, Yi-Fen Lai1, Tung-Wei Kao1,2, Tao-Chun Peng1, Yuan-Yung Lin3,4, Mu-Tsun Shih4,5, Wei-Liang Chen1,2,4 and Li-Wei Wu1,2,4

1Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China

2Division of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China

3Department of Otolaryngology–Head and Neck Surgery, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China

4Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan, Republic of China

5Division of Urology, Department of Surgery, Tri-Service General Hospital and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China

Correspondence to:

Li-Wei Wu, email: bigmouth0825@hotmail.com

Keywords: anthropometric parameters, insulin resistance, elderly, NHANES

Received: April 18, 2017     Accepted: July 07, 2017     Published: July 18, 2017

ABSTRACT

The homeostatic model assessment of insulin resistance (HOMA-IR) was used to measure the degree of insulin resistance (IR). Previous literature revealed that mid-arm muscle circumference (MAMC) is one of the anthropometric indicators for nutritional status and the relationship between MAMC and HOMA-IR remains uncertain in the obese and non-obese elderly individuals. The present study included 5,607 participants aged between 60 to 84 years old, using data from the 1999 to 2006 National Health and Nutrition Examination Survey (NHANES). To further explore the association between HOMA-IR and MAMC in the obese and non-obese elderly population using multivariate Cox regression analyses, we divided the participants into obese (BMI ≥ 30 kg/m2) group and non-obese (19 ≤ BMI < 30 kg/m2) group in this study; each group was then divided into quartiles based on their MAMC levels. A positive association was noted between the MAMC and HOMA-IR in all of the designed models initially. After adjusting for multiple covariates, a higher level of the MAMC was significantly associated with elevated HOMA-IR (P < 0.05) in the non-obesity group, which was not the case in the obesity group. Additionally, subjects in the higher quartiles of MAMC tended to have higher HOMA-IR with a significant association (P for trend = 0.003 in model 1; P for trend < 0.001 in model 2, 3, and 4). These results demonstrated that the MAMC can be an auxiliary indicator of HOMA-IR in non-obese elderly individuals and may have substantial additional value in screening for IR if well extrapolated.


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