Oncotarget

Research Papers:

Correlation of placental microbiota with fetal macrosomia and clinical characteristics in mothers and newborns

Jia Zheng _, Xin-Hua Xiao, Qian Zhang, Li-Li Mao, Miao Yu, Jian-Ping Xu and Tong Wang

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Oncotarget. 2017; 8:82314-82325. https://doi.org/10.18632/oncotarget.19319

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Abstract

Jia Zheng1, Xin-Hua Xiao1, Qian Zhang1, Li-Li Mao1, Miao Yu1, Jian-Ping Xu1 and Tong Wang1

1Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Correspondence to:

Xin-Hua Xiao, email: [email protected]

Keywords: fetal macrosomia, placenta, microbiota, 16S rRNA gene, clinical characteristics

Received: April 18, 2017     Accepted: June 24, 2017     Published: July 18, 2017

ABSTRACT

Substantial studies indicated that fetal macrosomia was associated with detrimental pregnancy outcomes, and increased susceptibility to metabolic diseases in later life. However, investigations into the association between placental microbiota and fetal macrosomia are limited. We aimed to profile the placental microbiota of fetal macrosomia and study whether they relate to clinical characteristics. Placenta samples were collected from fetal macrosomias and newborns with normal birth weight. The clinical characteristics, umbilical cord blood parameters were measured, and placental microbiota were sequenced and further analysed. The clinical characteristics of infants and mothers and umbilical cord blood parameters were significantly different between macrosomias and controls. The relative abundance of microbiota sequences revealed that microbial structures of the placenta differed significantly between macrosomia and controls. Regression analysis showed a cluster of key operational taxonomic unit (OTUs), phyla and genera were significantly correlated with body length, ponderal index and placenta weight, body weight increase during pregnancy of mothers, and cord blood IGF-1 and leptin concentrations. In conclusion, our study for the first time explored the relationship between placental microbiota profile and fetal macrosomia. It is novel in showing that a distinct placental microbiota profile is present in fetal macrosomia, and is associated with clinical characteristics of mothers and newborns.


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