Oncotarget

Research Papers:

Let-7a inhibits migration, invasion and tumor growth by targeting AKT2 in papillary thyroid carcinoma

Bin Zhou, Hailin Shan, Ying Su, Kai Xia, Runlong Zou and Qing Shao _

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Oncotarget. 2017; 8:69746-69755. https://doi.org/10.18632/oncotarget.19261

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Abstract

Bin Zhou1, Hailin Shan1, Ying Su1, Kai Xia1, Runlong Zou1 and Qing Shao1

1Department of Thyroid and Breast Surgery, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China

Correspondence to:

Qing Shao, email: [email protected]

Keywords: papillary thyroid carcinoma, let-7a, AKT2, tumor growth

Received: January 18, 2017     Accepted: June 19, 2017     Published: July 15, 2017

ABSTRACT

Papillary thyroid carcinoma (PTC) is the most common endocrine malignancy. Increasing evidence showed that microRNAs (miRNAs) play an important role in the PTC progression. In our study, the result showed that let-7a is significantly downregulated in PTC tissues and thyroid cancer cell lines. Overexpression of let-7a suppressed PTC cell proliferation, migration and invasion. Interestingly, we found that AKT2 was a direct target of let-7a and the expression levels of AKT2 were also observed to inversely correlate with let-7a expression in PTC tissues. Furthermore, enhancing AKT2 expression partially reversed the inhibitory effects of let-7a in PTC. Taken together, these findings suggest that let-7a acts as a novel suppressor by targeting the AKT2 gene and might be a candidate target for the development of novel therapeutic strategies to treat papillary thyroid carcinoma.


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