Oncotarget

Research Papers:

Effect of earlier-proteinuria on graft functions after one-year living donor renal transplantation

Zaiyou Dai, Luxi Ye, Dajin Chen, Xing Zhang, Meifang Wang, Rending Wang, Jianyong Wu _ and Jianghua Chen

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Oncotarget. 2017; 8:59103-59112. https://doi.org/10.18632/oncotarget.19260

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Abstract

Zaiyou Dai1,2,3,4,*, Luxi Ye1,2,3,*, Dajin Chen1,2,3, Xing Zhang1,2,3, Meifang Wang1,2,3, Rending Wang1,2,3, Jianyong Wu1,2,3 and Jianghua Chen1,2,3

1Department of The Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang, China

2Key Laboratory of Kidney Disease Prevention and Control Technology, Zhejiang, China

3The Third Grade Laboratory under The National State, Administration of Traditional Chinese Medicine, Zhejiang, China

4Department of Nephrology, The First People’s Hospital of Wenling, Zhejiang, China

*These authors have contributed equally to this work

Correspondence to:

Jianyong Wu, email: wujianyong@medmail.com.cn

Keywords: proteinuria, living donor renal transplantation, transplant outcome

Received: March 17, 2017    Accepted: April 27, 2017    Published: July 15, 2017

ABSTRACT

Background: Proteinuria is an indicator of subsequent renal function decline in most nephropathies and early proteinuria has been assumed to be a risk factor of poor kidney transplant outcomes. However, there is no information about the effect of earlier-proteinuria at the first week on short-term graft function after living donor renal transplantation.

Methods: Retrospective cohort study of 439 living donor kidney transplants to analyze the effect of early proteinuria at 7-day post-transplantation on short-term prognosis of living donor renal transplantation. Patients were stratified into 2 groups according to the definition of earlier-proteinuria: Group A as proteinuria < 0.4 g/24h and Group B as proteinuria ≥ 0.4 g/24h, and differences over the first year post-transplantation were analyzed.

Results: Patients with earlier-proteinuria ≥ 0.4 g/24h had a significantly higher 1-year proteinuria and lower 1-year graft function post-transplantation. Discrepancies of weight ratio of donor-recipient and mean artery pressure difference of recipient to donor influenced the urine protein excretion at the 7-day post-transplantation.

Conclusions: Earlier-proteinuria at 7-day after living donor renal transplantation was associated with short-term graft function. To eliminate the functional discrepancies between living donors and recipients could be viewed as a solution of reducing earlier-proteinuria.


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