Research Papers:

D-Dimer levels are correlated with disease activity in Crohn’s patients

Junwu Zhang, Zhen Guo, Wei Yang, Zhongliang Zhu, Wanzhong Kong, Sujie Zheng, Lei Jiang, Xianming Fei, Yanxia Chen _ and Jinlin Liu

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Oncotarget. 2017; 8:63971-63977. https://doi.org/10.18632/oncotarget.19250

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Junwu Zhang1, Zhen Guo2, Wei Yang3, Zhongliang Zhu3, Wanzhong Kong1, Sujie Zheng3, Lei Jiang3, Xianming Fei3, Yanxia Chen4 and Jinlin Liu3,5

1Department of Clinical Laboratory, Wenzhou Traditional Chinese Medicine Hospital, 325000 Wenzhou, China

2Department of Clinical Laboratory, Second Affiliated Hospital, School of Medicine, Zhejiang University, 310009 Hangzhou, China

3Department of Clinical Laboratory, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, 310014 Hangzhou, China

4Department of Rheumatology, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, 310014 Hangzhou, China

5Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, 310014 Hangzhou, China

Correspondence to:

Yanxia Chen, email: [email protected]

Jinlin Liu, email: [email protected]

Keywords: plasma d-dimer, coagulation function, fibrinolysis, Crohn’s disease, CDAI

Received: March 13, 2017    Accepted: June 04, 2017    Published: July 12, 2017


Various indices have been used to assess Crohn’s disease (CD). However, the question of whether the Crohn’s Disease Activity Index (CDAI) is associated with coagulation function has not been fully confirmed. In this study, we examined the association between CDAI and the coagulation and fibrinolysis parameters. In a retrospective and observational cohort study, the CDAI of 108 patients from two hospital centers was calculated, and its correlations with the prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), international normalization ratio (INR), fibrinogen (Fg) and plasma D-Dimer were investigated. Significant differences were found for PT, APTT, TT, INR, Fg and D-Dimer between the healthy controls and CD patients. However, no significant difference was found between the CDAI-High and CDAI-Low groups of CD patients. Moreover, the CDAI was positively correlated with the level of D-Dimer in CD patients of two hospitals, regardless of the detection method (hospital 1: r=0.3268, p= 0.0042; hospital 2: r=0.5553, p=0.0008). Among the blood coagulation and fibrinolysis parameters, the D-Dimer level was highly correlated with CDAI in CD patients. Thus, the level of D-Dimer expression may be a promising new marker for assessing CD disease activity.

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