Oncotarget

Meta-Analysis:

Meta-analysis of the association between the inflammatory potential of diet and colorectal cancer risk

Yu Fan, Xin Jin, Changfeng Man, Zhenjun Gao and Xiaoyan Wang _

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Oncotarget. 2017; 8:59592-59600. https://doi.org/10.18632/oncotarget.19233

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Abstract

Yu Fan1, Xin Jin1, Changfeng Man1, Zhenjun Gao2 and Xiaoyan Wang3

1Institute of Molecular Biology and Translational Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, Jiangsu, 212002, China

2Department of Digestive Disease, Central Hospital of Shanghai Qingpu District, Shanghai, 201700, China

3Department of Digestive Disease, The First People's Hospital of Suqian City, Suqian, Jiangsu, 223800, China

Correspondence to:

Xiaoyan Wang, email: tdszyy@126.com

Keywords: dietary inflammatory index, colorectal cancer, meta-analysis, systematic review

Received: May 18, 2017     Accepted: June 30, 2017     Published: July 14, 2017

ABSTRACT

Objectives: The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk.

Materials and Methods: The PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case–control studies investigating the association of the DII score with CRC risk were selected.

Results: Four prospective cohorts and four case–control studies, which enrolled a total of 880,380 participants, were included. The pooled adjusted risk ratio (RR) of CRC for the highest DII score versus the lowest category was 1.43 (95% confidence interval [CI]: 1.26–1.62). When stratified by study design, the RRs for the case–control and cohort studies were 1.27 (95% CI: 1.16–1.38) and 1.81 (95% CI: 1.48–2.22), respectively. Subgroup analysis showed that individuals with the highest category of DII score were independently associated with CRC risk in men (RR=1.51; 95% CI: 1.29–1.76), women (RR=1.25; 95% CI: 1.10–1.41), colon cancer (RR=1.39; 95% CI: 1.19–1.62), and rectal cancer (RR=1.32; 95% CI: 1.01–1.74). However, the pooled RR was 1.07 (95% CI: 0.87–1.31) for rectal cancer among the prospective cohort studies.

Conclusions: As estimated by a high DII score, pro-inflammatory diet is independently associated with increased CRC risk. This finding confirms that low inflammatory potential diet may reduce CRC risk. However, the gender- and cancer site-specific associations of the DII score with CRC risk need to be further investigated.


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