Research Papers:

Cerebral blood flow changes in remitted early- and late-onset depression patients

Wenxiang Liao, Ze Wang, Xiangrong Zhang _, Hao Shu, Zan Wang, Duan Liu and Zhijun Zhang

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:76214-76222. https://doi.org/10.18632/oncotarget.19185

Metrics: PDF 1642 views  |   HTML 3216 views  |   ?  


Wenxiang Liao1, Ze Wang2, Xiangrong Zhang1,3, Hao Shu1, Zan Wang1, Duan Liu1 and Zhijun Zhang1

1Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing, Jiangsu 210009, China

2Center for Cognition and Brain Disorders, Hangzhou Normal University, Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 311121, China

3Department of Geriatric Psychiatry, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China

Correspondence to:

Xiangrong Zhang, email: [email protected]

Zhijun Zhang, email: [email protected]

Keywords: early-onset depression, late-onset depression, cerebral blood flow

Received: January 23, 2017     Accepted: June 17, 2017     Published: July 12, 2017


Abnormal cerebral blood flow (CBF) is reportedly associated with major depressive disorder (MDD). We have investigated CBF changes in early-onset depression (EOD) and late-onset depression (LOD), and their impact on cognitive function. Thirty-two remitted EOD patients, 32 remitted LOD patients, and 43 age-matched healthy controls were recruited, and the pulsed arterial spin labeling data were scanned under 3.0T MRI and processed through voxel-by-voxel statistical analysis. Compared to healthy controls, LOD patients had decreased normalized CBF in the bilateral precuneus, cuneus, right fronto-cingulate-striatal areas, and right temporal, occipital and parietal lobes, but increased normalized CBF in the left frontal and temporal cortices and the cingulate gyrus. EOD patients had decreased normalized CBF in the left cerebellum and right calcarine/lingual/fusiform gyrus, and increased normalized CBF in right angular gyrus. LOD patients displayed hemispheric asymmetry in CBF, and had more regions with abnormal CBF than EOD patients. A significant correlation between abnormal CBF and impaired cognitive function was detected in LOD patients, but not EOD patients. These results demonstrate greater CBF abnormalities in LOD patients than EOD patients, and suggest these CBF changes may be associated with progressive degradation of cognitive function in LOD patients.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 19185