Histone demethylase JMJD2C: epigenetic regulators in tumors

Chengcheng Zhang, Zhongqi Wang, Qing Ji _ and Qi Li

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Oncotarget. 2017; 8:91723-91733. https://doi.org/10.18632/oncotarget.19176

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Chengcheng Zhang1,2, Zhongqi Wang2, Qing Ji1 and Qi Li1

1Department of Medical Oncology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

2Department of Medical Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China

Correspondence to:

Qing Ji, email: [email protected]

Qi Li, email: [email protected]

Keywords: histone demethylase, JMJD2C, epigenetic regulation, tumor

Received: May 16, 2017     Accepted: June 28, 2017     Published: July 12, 2017


Histone methylation is one of the major epigenetic modifications, and various histone methylases and demethylases participate in the epigenetic regulating. JMJD2C has been recently identified as one of the histone lysine demethylases. As one member of the Jumonji-C histone demethylase family, JMJD2C has the ability to demethylate tri- or di-methylated histone 3 and 2 in either K9 (lysine residue 9) or K36 (lysine residue 36) sites by an oxidative reaction, thereby affecting heterochromatin formation, genomic imprinting, X-chromosome inactivation, and transcriptional regulation of genes. JMJD2C was firstly found to involve in embryonic development and stem cell regulation. Afterwards, aberrant status of JMJD2C histone methylation was observed during the formation and development of various tumors, and it has been reported to play crucial roles in the progression of breast cancer, prostate carcinomas, osteosarcoma, blood neoplasms and so on, indicating that JMJD2C represents a promising anti-cancer target. In this review, we will focus on the research progress and prospect of JMJD2C in tumors, and provide abundant evidence for the functional application and therapeutic potential of targeting JMJD2C in tumors.

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