Oncotarget

Reviews:

Nanoformulations of curcumin: an emerging paradigm for improved remedial application

Meeta Gera, Neelesh Sharma, Mrinmoy Ghosh, Do Luong Huynh, Sung Jin Lee, Taesun Min, Taeho Kwon and Dong Kee Jeong _

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Oncotarget. 2017; 8:66680-66698. https://doi.org/10.18632/oncotarget.19164

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Abstract

Meeta Gera1,*, Neelesh Sharma2,*, Mrinmoy Ghosh1, Do Luong Huynh1, Sung Jin Lee3, Taesun Min1, Taeho Kwon1,4 and Dong Kee Jeong1,4

1Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju, Republic of Korea

2Division of Veterinary Medicine, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmi University of Agricultural Sciences and Technology, R.S. Pura, Jammu, India

3Department of Animal Biotechnology, College of Animal Bioscience and Technology, Kangwon National University, Gangwon-do, Republic of Korea

4Laboratory of Animal Genetic Engineering and Stem Cell Biology, Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju, Republic of Korea

*These authors contributed equally to this work

Correspondence to:

Dong Kee Jeong, email: [email protected], [email protected]

Taeho Kwon, email: [email protected]

Keywords: curcumin, herb, nano, nanoformulation, nanotechnology

Received: May 26, 2017     Accepted: June 29, 2017     Published: July 11, 2017

ABSTRACT

Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant Curcuma longa (L.) is universally acknowledged as “Wonder drug of life”. It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective. However, to improve its clinically relevant parameters, nanoformulation of curcumin is emerging as a novel substitute for their superior therapeutic modality. It enhances its aqueous solubility and targeted delivery to the tissue of interest that prompts to enhance the bioavailability, better drug conveyance, and more expeditious treatment. Subsequent investigations are endeavored to enhance the bio-distribution of native curcumin by modifying with felicitous nano-carriers for encapsulation. In this review, we specifically focus on the recent nanotechnology based implementations applied for overcoming the innate constraints of native curcumin and additionally the associated challenges which restrict its potential therapeutic applications both in vivo and in-vitro studies, as well as their detailed mechanism of action, have additionally been discussed.


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