Oncotarget

Meta-Analysis:

Prognostic role of Gli1 expression in breast cancer: a meta-analysis

Bilan Wang _, Ting Yu, Yuzhu Hu, Mengmeng Xiang, Haoning Peng, Yunzhu Lin, Lu Han and Lingli Zhang

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Oncotarget. 2017; 8:81088-81097. https://doi.org/10.18632/oncotarget.19080

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Abstract

Bilan Wang1,2,3, Ting Yu4, Yuzhu Hu4, Mengmeng Xiang4, Haoning Peng4, Yunzhu Lin1,2,3, Lu Han1,2,3 and Lingli Zhang1,2,3

1Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, 610041, PR China

2Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, 610041, PR China

3Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, 610041, PR China

4Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu, 610041, PR China

Correspondence to:

Bilan Wang, email: tt173217@163.com

Lingli Zhang, email: zhlingli@sina.com

Keywords: Gli1, breast cancer, prognosis

Received: May 31, 2017     Accepted: June 20, 2017     Published: July 07, 2017

ABSTRACT

Glioma-associated oncogene 1 (Gli1) is a critical transcriptional factor of Sonic hedgehog pathway which has been proved to participate in the initiation and progression of tumor in mammalians. However, its clinical value in breast cancer remains unknown. Thus, a meta-analysis was performed to clarify the association of Gli1 over-expression, clinic-pathological characteristics, molecular subtypes and prognosis in breast cancer. According to included criteria, 13 eligible studies containing 2816 patients all around the world were selected in this study. Our results indicated no significant association of Gli1 expression and histological grade (RR = 1.20, 95% CI: [0.98, 1.47]), T stage (RR = 1.05, 95% CI: [0.87, 1.27]), clinical stage (RR = 1.04, 95% CI: [0.93, 1.18]) and lymph node metastasis (RR = 1.12, 95% CI: [0.92, 1.37]). In addition, pooled RR showed no correlation of Gli1 expression and progesterone receptor (PR) (RR = 0.92, 95% CI: [0.70, 1.21]), estrogen receptor (ER) (RR = 1.03, 95% CI: [0.74, 1.42]), human epidermal growth factor receptor 2 (HER-2) (RR = 1.12, 95% CI: [0.90, 1.39]). Nonetheless, up-regulated Gli1 expression predicts shorter disease-free survival (DFS) (HR = 1.38, 95% CI: [1.05, 1.81]), 3-year survival (HR = 1.74, 95% CI: [1.28, 2.36]), 5-year survival (HR = 2.04, 95% CI: [1.62, 2.57]) and overall survival (OS) (HR = 2.05, 95% CI: [1.60, 2.64]). In conclusion, over-expression of Gli1 tends to progressive stages and is related to unfavorable prognosis of breast cancer, which may become a potential prognosis indicator and therapy target in breast cancer.


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