Oncotarget

Research Papers:

E3 ubiquitin ligase tripartite motif-containing 71 promotes the proliferation of non-small cell lung cancer through the inhibitor of kappaB-α/nuclear factor kappaB pathway

Hongjiu Ren, Yitong Xu, Qiongzi Wang, Jun Jiang, Wudumuli  , Linping Hui, Qingfu Zhang, Xiupeng Zhang, Enhua Wang, Limei Sun and Xueshan Qiu _

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Oncotarget. 2018; 9:10880-10890. https://doi.org/10.18632/oncotarget.19075

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Abstract

Hongjiu Ren1, Yitong Xu1, Qiongzi Wang1, Jun Jiang1, Wudumuli1, Linping Hui1,2, Qingfu Zhang1, Xiupeng Zhang1, Enhua Wang1, Limei Sun1 and Xueshan Qiu1

1Department of Pathology, College of Basic Medical Sciences and First Affiliated Hospital, China Medical University, Shenyang, China

2Fouth Affiliated Hospital, China Medical University, Shenyang, China

Correspondence to:

Xueshan Qiu, email: xsqiu@cmu.edu.cn

Limei Sun, email: lmsun@cmu.edu.cn

Keywords: tripartite motif-containing 71, non-small cell lung cancer, inhibitor of kappaB, nuclear factor kappaB, ubiquitination

Received: November 24, 2016     Accepted: June 15, 2017     Published: July 07, 2017

ABSTRACT

Tripartite motif-containing (TRIM) 71 belongs to the TRIM protein family. Many studies have shown that TRIM71 plays conserved roles in stem cell proliferation, differentiation, and embryonic development; however, the relationship between TRIM71 and tumorigenesis is not clear. In this study, we demonstrate that TRIM71 expression in non-small cell lung cancer (NSCLC) is associated with tumor size, lymph node metastasis, TNM stage, and poor prognosis. We found that TRIM71 was highly expressed in NSCLC cell lines compared with that in human normal bronchial epithelial cells. Moreover, by altering the expression of TRIM71 in selected cell lines, we found that TRIM71 promoted the proliferation of NSCLC cells through activation of the inhibitor of kappaB/nuclear factor kappaB pathway. These results suggested that TRIM71 plays a role in promoting the development of NSCLC.


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