Oncotarget

Research Papers:

Ethnic heterogeneity and prostate cancer mortality in Hispanic/Latino men: a population-based study

Felix M. Chinea, Vivek N. Patel, Deukwoo Kwon, Narottam Lamichhane, Chris Lopez, Sanoj Punnen, Erin N. Kobetz, Matthew C. Abramowitz and Alan Pollack _

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Oncotarget. 2017; 8:69709-69721. https://doi.org/10.18632/oncotarget.19068

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Abstract

Felix M. Chinea1,2, Vivek N. Patel1,2, Deukwoo Kwon2, Narottam Lamichhane1,2, Chris Lopez1,2, Sanoj Punnen2,3, Erin N. Kobetz2,4, Matthew C. Abramowitz1,2 and Alan Pollack1,2

1Department of Radiation Oncology, University of Miami, Miami, FL, USA

2Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA

3Department of Urology, University of Miami, Miami, FL, USA

4Division of Population Health and Computational Medicine, Department of Medicine, University of Miami, Miami, FL, USA

Correspondence to:

Alan Pollack, email: [email protected]

Keywords: prostate cancer, cancer specific mortality, Hispanic/Latino, health disparities, minority health

Received: January 17, 2017     Accepted: June 03, 2017     Published: July 06, 2017

ABSTRACT

Background: Few studies focus on prostate cancer (PCa) outcomes in Hispanic/Latino men. Our study explores whether Hispanic/Latino subgroups demonstrate significantly different prostate cancer-specific mortality (PCSM) relative to Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) men.

Methods: We extracted a population-based cohort of men diagnosed with local-regional PCa from 2000-2013 (n= 486,865). PCSM was measured in racial/ethnic groups: NHW (n=352,886), NHB (n= 70,983), Hispanic/Latino (n= 40,462), and Asian American/Pacific Islander (n= 22,534). PCSM was also measured in Hispanic/Latino subgroups: Mexican (n= 8,077), Puerto Rican (n= 1,284), South or Central American (n= 3,021), Cuban (n= 788), and Dominican (n= 300). We conducted univariable and multivariable analyses (MVA) to compare risk for PCSM.

Results: Compared to NHW men, results showed worse outcomes for NHB men with similar outcomes for Hispanic/Latino men. In MVA with NHW men as a reference, NHB (HR= 1.15, p <0.001) men had significantly worse PCSM and Hispanic/Latino (HR= 1.02, p= 0.534) men did not show a significant difference. In a second MVA, Puerto Rican (HR= 1.71, p <0.001) and Mexican (HR= 1.21, p= 0.008) men had significantly higher PCSM. With NHB men as a reference, the MVA showed Puerto Rican (HR= 1.50, p= 0.006) men with higher PCSM and Mexican (HR= 1.08, p= 0.307) men with no significant difference.

Conclusions: Our findings indicate previously unknown disparities in PCSM for Puerto Rican and Mexican American men.


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