Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients
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Yan Zhang2,*, Lingyan Liu1,*, Tai-Lang Yin4, Jing Yang4 and Cheng-Liang Xiong2,3
1School of Pharmaceutical Sciences, Capital Medical University, Beijing, China
2Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
3Wuhan Tongji Reproductive Medicine Hospital, Wuhan, Hubei Province, China
4Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China
*These authors contributed equally to this work and share co-first authorship
Cheng-Liang Xiong, email: firstname.lastname@example.org
Lingyan Liu, email: Lingyan@ccmu.edu.cn
Jing Yang, email: email@example.com
Keywords: PCOS, follicular fluid, metabolomics, NMR, oocyte quality
Received: May 04, 2017 Accepted: June 19, 2017 Published: July 06, 2017
Polycystic ovary syndrome (PCOS) is a common complex and heterogeneous disorder, affecting up to 10% women at reproductive age. It causes three fourth of the ovulatory infertility and PCOS patients often give poor IVF quality. Although some metabolic profiles have been investigated in PCOS patient sera and urine, the follicular fluid, providing fruitful biochemical information about oocyte environment during development has been ignored. In this work, based on NMR metabolomics approach, metabolic profile of follicular fluid of PCOS patients has been explored and compared with healthy controls. Significant increases of glycoprotein, acetate, cholesterol, significant decreases of lactic acid, glutamine, pyruvate, and alanine, have been discovered in PCOS follicular fluids. Furthermore, the Pearson correlations analysis indicated significant relationship existed between ART results and NMR detected follicular metabolites. All these results indicated that PCOS may induce dyslipidemia, low-grade inflammation, and disorder of glycolysis, pyruvate and amino acid metabolism in follicular fluids.
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