Oncotarget

Research Papers:

Follicular metabolic changes and effects on oocyte quality in polycystic ovary syndrome patients

Yan Zhang, Lingyan Liu, Tai-Lang Yin, Jing Yang and Cheng-Liang Xiong _

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:80472-80480. https://doi.org/10.18632/oncotarget.19058

Metrics: PDF 1764 views  |   HTML 2766 views  |   ?  


Abstract

Yan Zhang2,*, Lingyan Liu1,*, Tai-Lang Yin4, Jing Yang4 and Cheng-Liang Xiong2,3

1School of Pharmaceutical Sciences, Capital Medical University, Beijing, China

2Family Planning Research Institute/Center of Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China

3Wuhan Tongji Reproductive Medicine Hospital, Wuhan, Hubei Province, China

4Reproductive Medicine Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China

*These authors contributed equally to this work and share co-first authorship

Correspondence to:

Cheng-Liang Xiong, email: clxiong951@sina.com

Lingyan Liu, email: Lingyan@ccmu.edu.cn

Jing Yang, email: dryangqing@hotmail.com

Keywords: PCOS, follicular fluid, metabolomics, NMR, oocyte quality

Received: May 04, 2017     Accepted: June 19, 2017     Published: July 06, 2017

ABSTRACT

Polycystic ovary syndrome (PCOS) is a common complex and heterogeneous disorder, affecting up to 10% women at reproductive age. It causes three fourth of the ovulatory infertility and PCOS patients often give poor IVF quality. Although some metabolic profiles have been investigated in PCOS patient sera and urine, the follicular fluid, providing fruitful biochemical information about oocyte environment during development has been ignored. In this work, based on NMR metabolomics approach, metabolic profile of follicular fluid of PCOS patients has been explored and compared with healthy controls. Significant increases of glycoprotein, acetate, cholesterol, significant decreases of lactic acid, glutamine, pyruvate, and alanine, have been discovered in PCOS follicular fluids. Furthermore, the Pearson correlations analysis indicated significant relationship existed between ART results and NMR detected follicular metabolites. All these results indicated that PCOS may induce dyslipidemia, low-grade inflammation, and disorder of glycolysis, pyruvate and amino acid metabolism in follicular fluids.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 19058