Research Papers:

Quantitative evaluation of Gd-EOB-DTPA uptake in focal liver lesions by using T1 mapping: differences between hepatocellular carcinoma, hepatic focal nodular hyperplasia and cavernous hemangioma

Zhenpeng Peng, Chang Li, Tao Chan, Huasong Cai, Yanji Luo, Zhi Dong, Zi-Ping Li _ and Shi-Ting Feng

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Oncotarget. 2017; 8:65435-65444. https://doi.org/10.18632/oncotarget.18918

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Zhenpeng Peng1,*, Chang Li1,*, Tao Chan2, Huasong Cai1, Yanji Luo1, Zhi Dong1, Zi-Ping Li1 and Shi-Ting Feng1

1Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, Guangdong, China

2Department of Diagnostic Radiology, The University of Hong Kong, Pokfulam, Hong Kong

*These authors have contributed equally to this work

Correspondence to:

Zi-Ping Li, email: [email protected]

Shi-Ting Feng, email: [email protected]

Keywords: Gd-EOB-DTPA, MRI, T1 mapping, focal liver lesion, discriminant analysis

Received: December 06, 2016     Accepted: June 14, 2017     Published: July 01, 2017


Objectives: To investigate the difference of T1 relaxation time on Gd-EOB-DTPA-enhanced MRI in hepatocellular carcinoma (HCC), hepatic focal nodular hyperplasia (FNH) and cavernous hemangioma of liver (CHL), and to quantitatively evaluate the uptake of Gd-EOB-DTPA in these three focal liver lesions (FLLs).

Results: The T1P of CHL was significantly higher than those of HCC and FNH (P < 0.05). Reduction of T1 relaxation time on hepatobiliary phase could be observed in all three types of lesions. There were significant differences of T1P, T1E, T1D and T1D% between FNH, CHL and HCC (P < 0.001). Spearman correlation analysis revealed that T1D% was the best indicator for diagnostic differentiation, with a correlation coefficient of 0.702. Discriminant analysis using three variables (T1P, T1E, and T1D%) showed that the classification accuracy was 88.2%.

Materials and Methods: 74 patients diagnosed with focal liver lesions underwent Gd-EOB-DTPA-enhanced MRI including T1 mapping were enrolled, consisting of 51 HCCs, 10 FNHs, and 13 CHLs. T1 relaxation times of these lesions were measured on pre-contrast (T1P) and on hepatobiliary phase images at 20 minute after contrast (T1E). The reduction of T1 relaxation time on hepatobiliary (T1D) and the percentage reduction (T1D%) was calculated. The differences of T1P, T1E, T1D and T1D% in these FLLs were analyzed. The usefulness of these parameters for classification of FLLs was evaluated.

Conclusions: Uptake of Gd-EOB-DTPA is different between in HCC, FNH and CHL. These three lesions can be distinguished using T1 mapping.

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