Research Papers:

Xuefu zhuyu decoction improves cognitive impairment in experimental traumatic brain injury via synaptic regulation

Jing Zhou, Tao Liu, Hanjin Cui, Rong Fan, Chunhu Zhang, Weijun Peng, Ali Yang, Lin Zhu, Yang Wang _ and Tao Tang

PDF  |  HTML  |  Supplementary Files  |  How to cite

Oncotarget. 2017; 8:72069-72081. https://doi.org/10.18632/oncotarget.18895

Metrics: PDF 3035 views  |   HTML 3132 views  |   ?  


Jing Zhou1, Tao Liu1,2, Hanjin Cui1, Rong Fan1, Chunhu Zhang1, Weijun Peng3, Ali Yang4, Lin Zhu1, Yang Wang1 and Tao Tang1

1Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 410008 Changsha, China

2Department of Gerontology, Traditional Chinese Medicine Hospital Affiliate to Xinjiang Medical University, 830000 Urumqi, China

3Department of Traditional Chinese Medicine, 2nd Xiangya Hospital, Central South University, 410011 Changsha, China

4Department of Neurology, Henan Province People’ Hospital, 450003 Zhengzhou, China

Correspondence to:

Yang Wang, email: [email protected]

Tao Tang, email: [email protected]

Keywords: xuefu zhuyu decoction, traditional Chinese medicine, traumatic brain injury, cognitive impairment, synaptic regulation

Received: February 24, 2017     Accepted: June 12, 2017     Published: June 30, 2017


An overarching consequence of traumatic brain injury (TBI) is the cognitive impairment. It may hinder individual performance of daily tasks and determine people’s subjective well-being. The damage to synaptic plasticity, one of the key mechanisms of cognitive dysfunction, becomes the potential therapeutic strategy of TBI. In this study, we aimed to investigate whether Xuefu Zhuyu Decoction (XFZYD), a traditional Chinese medicine, provided a synaptic regulation to improve cognitive disorder following TBI. Morris water maze and modified neurological severity scores were performed to assess the neurological and cognitive abilities. The PubChem Compound IDs of the major compounds of XFZYD were submitted into BATMAN-TCM, an online bioinformatics analysis tool, to predict the druggable targets related to synaptic function. Furthermore, we validated the prediction through immunohistochemical, RT-PCR and western blot analyses. We found that XFZYD enhanced neuroprotection, simultaneously improved learning and memory performances in controlled cortical impact rats. Bioinformatics analysis revealed that the improvements of XFZYD implied the Long-term potentiation relative proteins including NMDAR1, CaMKII and GAP-43. The further confirmation of molecular biological studies confirmed that XFZYD upregulated the mRNA and protein levels of NMDAR1, CaMKII and GAP-43. Pharmacological synaptic regulation of XFZYD could provide a novel therapeutic strategy for cognitive impairment following TBI.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 18895