Combination of cadherin-17 and SATB homeobox 2 serves as potential optimal makers for the differential diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma
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Tingting Bian1,*, Jinli Zhao2,*, Jia Feng1, Qing Zhang1, Li Qian1, Jian Liu3, Daishan Jiang4, Yifei Liu1 and Jianguo Zhang1
1Department of Pathology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China
2Department of Radiology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China
3Department of Chemotherapy, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China
4Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, P.R. China
*These authors have contributed equally to this work
Yifei Liu, email: [email protected]
Jianguo Zhang, email: [email protected]
Keywords: pulmonary enteric adenocarcinoma, metastatic colorectal adenocarcinoma, cadherin-17, SATB homeobox 2, immunohistochemistry
Received: February 06, 2017 Accepted: June 02, 2017 Published: June 28, 2017
Background: Pulmonary enteric adenocarcinoma (PEAC), a rare type of non-small cell lung cancer, has similar histological and immunohistochemical morphology to colorectal adenocarcinoma. Cadherin-17 (CDH17) and SATB homeobox 2 (SATB2) immunoexpression have recently been demonstrated in colorectal adenocarcinoma. In this study, we evaluated the value of CDH17 and SATB2 in the diagnosis of pulmonary enteric adenocarcinoma and metastatic colorectal adenocarcinoma. Methods: A total of 13 PEAC cases and 27 metastatic colorectal adenocarcinoma cases were enrolled in our cohort study. We analyzed the expressions of CK7, CK20, CDX-2, villin, cadherin-17 (CDH17), and SATB homeobox 2 (SATB2) using immunohistochemistry. Staining intensity and percentage of positive-staining cells were recorded. Sensitivity and specificity values for immunostains, individually and in combination, were computed and compared. Results: Combining CDH17 and SATB2 resulted in high sensitivity (76.92%) and specificity (100%). In our study, the use of CK7+, napsin A+, TTF-1+, napsin A+TTF-1+ in combination with CDH17-/SATB2- had a higher area under the curve compared to the combination CDH17-/SATB2-. However, no significant differences were observed between the combination CDH17-/SATB2- and other combinations (P>0.05). Conclusions: In combination, CDH17 and SATB2 serve as potential optimal markers for the differential diagnosis of PEAC and metastatic colorectal adenocarcinoma.
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