Oncotarget

Meta-Analysis:

Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and susceptibility to osteosarcoma: a meta-analysis and literature review

Yanhua Jiang _, Xiandi Wang, Yi Cheng, Jun Peng, Jiwei Xiao, Dingbo Tang and Ying Yi

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Oncotarget. 2017; 8:97571-97583. https://doi.org/10.18632/oncotarget.18813

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Abstract

Yanhua Jiang1,*, Xiandi Wang2,*, Yi Cheng1, Jun Peng1, Jiwei Xiao1, Dingbo Tang1 and Ying Yi1

1Department of Orthopedics, Sichuan Cancer Hospital, Chengdu, China

2Department of Orthopedics, Huashan Hospital, Fudan University, Shanghai, China

*These authors contributed equally to this work

Correspondence to:

Yanhua Jiang, email: wusijiang@yeah.net

Keywords: osteosarcoma, inflammatory gene, polymorphism, meta-analysis

Received: April 27, 2017     Accepted: June 12, 2017     Published: June 29, 2017

ABSTRACT

Associations between inflammatory gene polymorphisms (TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G, TGF-β1 29T/C, IL-6 174G/C and IL-10 1082A/G) and osteosarcoma (OS) risk remain unclear. We conducted a systematic search to retrieve studies that investigated associations between inflammatory gene polymorphisms and OS risk. Nine studies that met the inclusion criteria were finally recruited in this meta-analysis. Overall, there was a significant association between TNF-α 308G/A, IL-10 1082A/G and OS risk, while there was no significant association between TNF-α 238G/A, TNF-β 252A/G and IL-6 174G/C and OS risk. Our subgroup analysis showed a significant association between IL-6 174G/C and IL-10 1082A/G and OS risk in Asians, while no such significant correlation was observed with TNF-α 308G/A, TNF-α 238G/A, TNF-β 252A/G and TGF-β1 29T/C polymorphisms. In Caucasians, there was a significant association between TNF-α 238G/A and the decreased incidence of OS. In conclusion, inflammatory gene polymorphisms play a key role in the occurrence and progression of OS. IL-6 174G/C polymorphism was obviously associated with OS risk in Asians, while TNF-α 238G/A polymorphism seemed to be associated with the decreased susceptibility to OS in Caucasians as Altman and Bland test indicated. Although controversial results were observed between IL-10 1082A/G and OS risk in Asians and Caucasians, it is difficult to make a definite conclusion about the role of IL-10 1082A/G polymorphism in the etiology of OS because our Altman and Bland test showed no good evidence to support a different effect in Asians and Caucasians.


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