MiR-200c inhibits bladder cancer progression by targeting lactate dehydrogenase A
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Daozhang Yuan1, Shunsheng Zheng1, Liyan Wang1, Jing Li1, Jianan Yang1, Bin Wang1, Xiong Chen2 and Xiaobo Zhang2
1Department of Urology, Cancer Center of Guangzhou Medical University, Guangzhou, People’s Republic of China
2Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
Daozhang Yuan, email: [email protected]
Xiaobo Zhang, email: [email protected]
Keywords: microRNA, miR-200c, LDHA, bladder cancer, proliferation
Received: November 09, 2016 Accepted: June 02, 2017 Published: June 28, 2017
Lactate dehydrogenase A (LDHA) is overexpressed in various cancers. We investigated LDHA expression and function in bladder cancer. We demonstrate that LDHA is up-regulated in bladder cancer cells and promotes proliferation, invasion, and glycolysis. Additionally, we found that microRNA (miR)-200c directly targets LDHA in bladder cancer cells. Ectopic expression of miR-200c inhibited LDHA-induced glycolysis, cell proliferation, and invasion. Thus, targeting LDHA through miR-200c is a potential therapeutic strategy in bladder cancer.
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