Oncotarget

Research Papers:

Linc00152 suppresses apoptosis and promotes migration by sponging miR-4767 in vascular endothelial cells

Wei Teng, Chunguang Qiu _, Zhaohui He, Guoliang Wang, Yongliang Xue and Xuezhi Hui

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:85014-85023. https://doi.org/10.18632/oncotarget.18777

Metrics: PDF 1128 views  |   HTML 2358 views  |   ?  


Abstract

Wei Teng1,2, Chunguang Qiu1, Zhaohui He2, Guoliang Wang2, Yongliang Xue2 and Xuezhi Hui2

1Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

2Department of Cardiology, The First Affiliated Hospital of Henan University, Kaifeng 475000, China

Correspondence to:

Chunguang Qiu, email: chunguangqiuedu@163.com

Keywords: vascular endothelial cells, linc00152, cell apoptosis and migration, miR-4767, ceRNA

Received: February 23, 2017    Accepted: May 22, 2017    Published: June 28, 2017

ABSTRACT

Dysfunction of vascular endothelial cells (VECs), such as increased apoptosis and diminished migration, is closely connected with most cardiovascular diseases and angiogenesis-related events. LncRNAs have been involved in regulation of many pathological processes, but their roles in vascular endothelial function are hardly underreported. Here, we explore the role of a intergenic lncRNA named linc00152 in the apoptosis and migration of VECs. We found that linc00152 was downregulated in human umbilical vein VECs (HUVECs) in a dose- and time-dependent manner following treatment with oxLDL, which is a typical proinflammatory factor in the initiation and progression of vascular endothelial dysfunction. Gain- and loss-function experiments indicated that linc00152 distinctly inhibited apoptosis and improved migration in oxLDL-treated HUVECs. By sponging miR-4767, linc00152 positively regulated the expression of Bcl2L12 and EGFR proteins. Moreover, blocking miR-4767 rescued the decrease of Bcl2L12 and EGFR caused by linc00152 knockdown, as well as the changes in cell apoptosis and migration. Our findings propose a novel role of linc00152 in the improvement of vascular endothelial function and a potential target for the therapy of some cardiovascular diseases.


Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 18777