Oncotarget

Clinical Research Papers:

Positive Helicobacter pylori status is associated with better overall survival for gastric cancer patients: evidence from case-cohort studies

Xuqian Fang, Kun Liu, Jialin Cai, Fangxiu Luo, Fei Yuan and Peizhan Chen _

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Oncotarget. 2017; 8:79604-79617. https://doi.org/10.18632/oncotarget.18758

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Abstract

Xuqian Fang1,2,*, Kun Liu3,*, Jialin Cai1, Fangxiu Luo2, Fei Yuan2 and Peizhan Chen1

1 Translational Medicine Research Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China

2 Department of Pathology, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China

3 Department of Surgery, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China

* These authors have contributed equally to this work

Correspondence to:

Peizhan Chen, email:

Fei Yuan, email:

Keywords: Helicobacter pylori, gastric cancer, overall survival, disease-free survival, meta-analysis

Received: March 27, 2017 Accepted: May 15, 2017 Published: June 28, 2017

Abstract

Helicobacter pylori (H. pylori) infection increases the gastric cancer risk; however, the influences of H. pylori infection status on the outcomes for gastric cancer patients have not yet clearly defined. Herein, we systematically assessed the epidemiological studies regarding the associations between the H.pylori infection status at diagnosis and the prognosis for gastric cancer patients with the meta-analysis methods. Thirty-three eligibility studies with 8,199 participants that had determined the H.pylori infection status and the outcomes for gastric cancer patients were identified through searching the PubMed and MEDLINE databases updated to March 1st, 2017. The random-effects model suggested that positive H. pylori infection was associated with better overall survival with the pooled hazard ratio (HR) was 0.79 [95% confidence interval (CI) = 0.66-0.93; Q = 134.86, df = 32, P-heterogeneity < 0.001; I2 = 76.3%] compared to negative patients. The association was found to be more prominent in studies with higher quality, longer following-up time and more sensitive detection methods. An inverse but not statistically significant association between the H.pylori status and the disease-free survival of the patients (pooled HR = 0.84, 95% CI = 0.61-1.05;Q = 30.48, df = 11, P-heterogeneity = 0.001; I2 = 63.9%) was found, while no significant association was noticed in any subgroup analyses. These results suggested that gastric cancer patients with positive H.pylori infection status at diagnosis have better overall survival compared to negative; however, more studies are warranted to confirm the results and elucidate the underlying mechanisms.


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