Oncotarget

Research Papers:

Younger age at surgery and lesser seizure frequency as prognostic factors for favorable seizure-related outcome after glioma resection in adults

Zhe-Ren Tan, Xiao-Yan Long, Zhi-Quan Yang, Jun Huang, Qing-Yuan Hu, Hao-Dong Yang and Guo-Liang Li _

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Oncotarget. 2017; 8:93444-93449. https://doi.org/10.18632/oncotarget.18726

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Abstract

Zhe-Ren Tan1,*, Xiao-Yan Long1,*, Zhi-Quan Yang2, Jun Huang2, Qing-Yuan Hu3, Hao-Dong Yang3 and Guo-Liang Li1

1Department of Neurology, Xiangya Hospital, The Central South University, Changsha 410008, China

2Department of Neurosurgery, Xiangya Hospital, The Central South University, Changsha 410008, China

3Ya Li High School, Changsha 410005, China

*These authors have contributed equally to this work

Correspondence to:

Guo-Liang Li, email: glglgl09@126.com, 409685656@qq.com

Keywords: glioma, brain tumor, epilepsy, prognostic factor, glioma resection

Received: September 30, 2016     Accepted: April 11, 2017     Published: June 27, 2017

ABSTRACT

The identification of variables predictive of good seizure control following surgical tumor resection in adult glioma patients with tumor-related epilepsy would greatly benefit treatment decisions. Therefore, we analyzed the clinical data of adult patients with tumor-related epilepsy who underwent tumor resection at our institute between November 2011 and August 2013. Patients were divided into seizure-free (Engel Ia) and unfavorable outcome groups (Engel Ib–IV), and potential prognostic factors were analyzed. Of 90 patients, 61 (68%) had a favorable outcome at an average of 3 years after surgery. Our analyses indicated that younger age at surgery (P=0.048) and rare seizure frequency (P=0.006) were associated with significantly more favorable postoperative seizure-related outcomes. In conclusion, younger age at surgery and lesser seizure frequency were independent predictors of favorable epileptic seizure control after glioma resection in adults. Thus, early surgical resection is necessary for achieving favorable seizure outcome.


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