Younger age at surgery and lesser seizure frequency as prognostic factors for favorable seizure-related outcome after glioma resection in adults
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Zhe-Ren Tan1,*, Xiao-Yan Long1,*, Zhi-Quan Yang2, Jun Huang2, Qing-Yuan Hu3, Hao-Dong Yang3 and Guo-Liang Li1
1Department of Neurology, Xiangya Hospital, The Central South University, Changsha 410008, China
2Department of Neurosurgery, Xiangya Hospital, The Central South University, Changsha 410008, China
3Ya Li High School, Changsha 410005, China
*These authors have contributed equally to this work
Keywords: glioma, brain tumor, epilepsy, prognostic factor, glioma resection
Received: September 30, 2016 Accepted: April 11, 2017 Published: June 27, 2017
The identification of variables predictive of good seizure control following surgical tumor resection in adult glioma patients with tumor-related epilepsy would greatly benefit treatment decisions. Therefore, we analyzed the clinical data of adult patients with tumor-related epilepsy who underwent tumor resection at our institute between November 2011 and August 2013. Patients were divided into seizure-free (Engel Ia) and unfavorable outcome groups (Engel Ib–IV), and potential prognostic factors were analyzed. Of 90 patients, 61 (68%) had a favorable outcome at an average of 3 years after surgery. Our analyses indicated that younger age at surgery (P=0.048) and rare seizure frequency (P=0.006) were associated with significantly more favorable postoperative seizure-related outcomes. In conclusion, younger age at surgery and lesser seizure frequency were independent predictors of favorable epileptic seizure control after glioma resection in adults. Thus, early surgical resection is necessary for achieving favorable seizure outcome.
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