Research Papers:

LEPR gene Gln223Arg polymorphism and type 2 diabetes mellitus: a meta-analysis of 3,367 subjects

Yan-Yan Li _, Hui Wang, Xin-Xing Yang, Jing-Jing Wu, Hong-Yu Geng, Hyun Jun Kim, Zhi-Jian Yang and Lian-Sheng Wang

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Oncotarget. 2017; 8:61927-61934. https://doi.org/10.18632/oncotarget.18720

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Yan-Yan Li1,*, Hui Wang2,*, Xin-Xing Yang1, Jing-Jing Wu3, Hong-Yu Geng1, Hyun Jun Kim4, Zhi-Jian Yang2 and Lian-Sheng Wang2

1Department of Gerontology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

2Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

3Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

4Department of Physiology, University of Cincinnati, Cincinnati, OH 45267, United States of America

*These authors have contributed equally to this work

Correspondence to:

Yan-Yan Li, email: lyynjmu123@126.com

Keywords: leptin receptor, Gln223Arg, polymorphism, type 2 diabetes mellitus

Received: February 09, 2017    Accepted: May 22, 2017    Published: June 27, 2017


Background: The Leptin receptor (LEPR) Gln223Arg gene polymorphism has been associated with an increased susceptibility to Type 2 diabetes mellitus (T2DM). Results from various studies, however, are inconsistent.

Objective and methods: To better elucidate the association of LEPR Gln223Arg gene polymorphism with T2DM in the Chinese population, a meta-analysis of 3,367 subjects from seven independent studies was performed. The pooled odds ratios (ORs) and corresponding 95% confidence intervals (95% CI) were evaluated by the fixed-effects model.

Results: A significant relationship between LEPR Gln223Arg gene polymorphism and T2DM in the Chinese population was found under allele (OR: 1.432, 95% CI: 1.211-1.694, P=2.67×10-5), dominant (OR: 1.466, 95% CI: 1.215-1.769, P=6.33×10-5), recessive (OR: 0.539, 95% CI: 0.303-0.960, P=0.036), heterozygous (OR: 0.700, 95% CI: 0.577-0.849, P=3.06×10-4), and homozygous (OR: 0.472, 95% CI: 0.265-0.839, P=0.011) genetic models.

Conclusions: LEPR Gln223Arg gene polymorphism was associated with an increased risk of T2DM in the Chinese population. Therefore, Chinese carriers of the G allele of LEPR Gln223Arg gene polymorphism may be more susceptible to T2DM than the general population.

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