The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide

Xuhua Duan; Tengfei Li; Xinwei Han; Jianzhuang Ren; Pengfei Chen; Hao Li; Shaojun Gong

doi:10.18632/oncotarget.18677

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Research Papers:

The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide

Xuhua Duan, Tengfei Li, Xinwei Han _, Jianzhuang Ren, Pengfei Chen, Hao Li and Shaojun Gong

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Oncotarget. 2017; 8:90905-90915. https://doi.org/10.18632/oncotarget.18677

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Abstract

Xuhua Duan1,*, Tengfei Li1,*, Xinwei Han1,#, Jianzhuang Ren1,#, Pengfei Chen1, Hao Li1 and Shaojun Gong1

1Department of Interventional Radiology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, People’s Republic of China

*These authors contributed equally to this work and share co-first authorship

#These authors contributed equally to this work

Correspondence to:

Xinwei Han, email: [email protected]

Jianzhuang Ren, email: [email protected]

Keywords: andrographolide, As₂O₃, HepG2 cells, apoptosis, EphB4

Received: February 14, 2017 Accepted: June 02, 2017 Published: June 27, 2017

ABSTRACT

High concentrations of arsenic trioxide (As₂O₃) are used to treat acute promyelocytic leukemia and solid tumors, with negative side effects to normal cells. Andrographolide is a traditional Chinese medicine that exerts anti-cancer, anti-inflammatory, anti-virus, and anti-diabetic effects. Here, we tested the effects of combined andrographolide with As₂O₃ against hepatocellular carcinoma (HCC). We found that by increasing apoptosis, andrographolide synergistically enhanced the anti-tumor effects of As2O3 in HepG2 cells in vitro and in vivo. Furthermore, results from our microarray assays and experiments with mouse xenografts showed that EphB4 was downregulated by the combination of As₂O₃ plus andrographolide. These findings suggest that the combination of andrographolide and As₂O₃ could yield therapeutic benefits in the treatment of HCC.

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Research Papers:

The antitumor effect of arsenic trioxide on hepatocellular carcinoma is enhanced by andrographolide

Abstract