Interplay between apoptosis and autophagy in colorectal cancer

Hao-Ran Qian _, Zhao-Qi Shi, He-Pan Zhu, Li-Hu Gu, Xian-Fa Wang and Yi Yang

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Oncotarget. 2017; 8:62759-62768. https://doi.org/10.18632/oncotarget.18663

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Hao-Ran Qian1,*, Zhao-Qi Shi1, He-Pan Zhu1, Li-Hu Gu1, Xian-Fa Wang1 and Yi Yang2,*

1Department of General Surgery, Institute of Minimally Invasive, Surgery of Zhejiang University, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, Zhejiang, PR China

2Department of Pharmacology, Hangzhou Key Laboratory of Medical Neurobiology, School of Medicine, Hangzhou Normal University, Hangzhou 310036, Zhejiang, PR China

*These authors have contributed equally to this work

Correspondence to:

Hao-Ran Qian, email: [email protected]

Yi Yang, email: [email protected]

Keywords: colorectal cancer, autophagy, apoptosis, cross-talk

Received: March 22, 2017     Accepted: May 15, 2017     Published: June 27, 2017


Autophagy and apoptosis are two pivotal mechanisms in mediating cell survival and death. Cross-talk of autophagy and apoptosis has been documented in the tumorigenesis and progression of cancer, while the interplay between the two pathways in colorectal cancer (CRC) has not yet been comprehensively summarized. In this study, we outlined the basis of apoptosis and autophagy machinery firstly, and then reviewed the recent evidence in cellular settings or animal studies regarding the interplay between them in CRC. In addition, several key factors that modulate the cross-talk between autophagy and apoptosis as well as its significance in clinical practice were discussed. Understanding of the interplay between the cell death mechanisms may benefit the translation of CRC treatment from basic research to clinical use.

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