Research Papers:

Value of SOFA, APACHE IV and SAPS II scoring systems in predicting short-term mortality in patients with acute myocarditis

Dating Sun, Hu Ding, Chunxia Zhao, Yuanyuan Li, Jing Wang, Jiangtao Yan _ and Dao Wen Wang

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Oncotarget. 2017; 8:63073-63083. https://doi.org/10.18632/oncotarget.18634

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Dating Sun1,*, Hu Ding1,*, Chunxia Zhao1, Yuanyuan Li1, Jing Wang1, Jiangtao Yan1 and Dao Wen Wang1

1Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, People’s Republic of China

*These authors have contributed equally to this work

Correspondence to:

Jiangtao Yan, email: [email protected]

Dao Wen Wang, email: [email protected]

Keywords: myocarditis, mortality, scoring systems

Received: February 28, 2017     Accepted: May 22, 2017     Published: June 27, 2017


Acute myocarditis is an uncommon and potentially life-threatening disease. Scoring systems are essential for predicting outcome and evaluating the therapy effect of adult patients with acute myocarditis. The aim of this study was to determine the value of the Sequential Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation IV (APACHE IV) and second Simplified Acute Physiology Score (SAPS II) scoring systems in predicting short-term mortality of these patients. We retrospectively analyzed data from 305 adult patients suffering from acute myocarditis between April 2005 and August 2016. The association between the value of admission SOFA, APACHE IV and SAPS II scores and risk of short-term mortality was determined. Multivariate Cox analysis showed that SOFA, APACHE IV and SAPS II scores were independent risk factors of death in patients with acute myocarditis. For each scoring system, Kaplan–Meier analysis showed that the cumulative short-term mortality was significantly higher in patients with higher admission scores compared with those with lower admission scores. For the prediction of short-term mortality in a patient with acute myocarditis, SAPS II had the highest accuracy followed by the APACHE IV and SOFA scores.

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