Clinical Research Papers:

Association between fibrinogen level and the severity of coronary stenosis in 418 male patients with myocardial infarction younger than 35 years old

Xiong-Yi Gao, Bing-Yang Zhou, Min-Zhou Zhang, Xi Zhao, Ping Qing, Cheng-Gang Zhu, Na-Qiong Wu, Yuan-Lin Guo, Ying Gao, Xiao-Lin Li, Yao Wang, Geng Liu, Qian Dong, Li-Heng Guo and Jian-Jun Li _

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Oncotarget. 2017; 8:81361-81368. https://doi.org/10.18632/oncotarget.18578

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Xiong-Yi Gao1,2,*, Bing-Yang Zhou1,*, Min-Zhou Zhang2,*, Xi Zhao1, Ping Qing1, Cheng-Gang Zhu1, Na-Qiong Wu1, Yuan-Lin Guo1, Ying Gao1, Xiao-Lin Li1, Yao Wang1, Geng Liu1, Qian Dong1, Li-Heng Guo2 and Jian-Jun Li1

1Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China

2Division of Chest Pain Center, Guangdong Provincial Hospital of Chinese Medicine, The 2nd Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, 510120, China

*These authors contributed equally to this work

Correspondence to:

Jian-Jun Li, email: [email protected]

Keywords: fibrinogen, myocardial infarction, coronary artery, very young patients, Gensini score

Received: August 23, 2016     Accepted: May 21, 2017     Published: June 20, 2017


Fibrinogen (Fib) is a useful marker for predicting the severity of coronary artery disease (CAD) in adult population. However, whether Fib can be a predictor for the presence and severity of CAD in very young MI patients (≤35 years old) remains to be determined. A total of 418 males from 61,863 patients with MI who were under 35 years old were sequentially recruited in our study. The patients were divided into two main groups and three subgroups according to coronary angiograph and Gensini score (GS) system: no coronary artery stenosis (group A), the results of the coronary artery stenosis (group B); low GS, intermediate GS and high GS. Data indicated that Fib, body mass index, current smoking, white blood cell count (WBCC) and GS were significantly higher in group B than those in group A (all P < 0.01). Moreover, there were significant differences in Fib, mean age, diabetes mellitus, family history of CAD, WBCC, left ventricular ejection fraction, and GS between high GS and low GS subgroups (all P < 0.01). A positive correlation between Fib levels and GS was found (r = 0.242, p < 0.001). Receiver operating characteristics curve analysis demonstrated that the best cut-off level of Fib predicting the severity of coronary stenosis was 3.475g/L (sensitivity 64%; specificity 70%) and the area under the curve was 0.656. Fib was also independently associated with high GS (OR=2.173, 95%CI 1.011–4.670, P = 0.047) after adjusting for potential confounders. In conclusion, Fib is significantly related to the presence and severity of coronary stenosis in male patients with MI under 35 years old.

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