Clinical Research Papers:
Effects of liraglutide on hemodynamic parameters in patients with heart failure
Metrics: PDF 764 views | HTML 1262 views | ?
Jin Ying Zhang1, Xin Yun Wang1 and Xiang Wang1
1Department of Emergency, Binzhou Medical University Hospital, Binzhou, Shandong, China
Jin Ying Zhang, email: firstname.lastname@example.org
Keywords: glucagon-like peptide-1, heart failure, hemodynamic, pulse indicator continuous cardiac output, left ventricular function
Received: October 19, 2016 Accepted: June 02, 2017 Published: June 19, 2017
Glucagon-like peptide-1 analogues improve left ventricular function in patients with acute myocardial infarction. This study aimed to evaluate the effects of liraglutide on hemodynamic parameters in patients with heart failure. A total of 78 patients with heart failure were enrolled in this study between August 2014 and November 2015. Of these, 52 patients were randomized 1:1 to receive either liraglutide or placebo for 7 days. Hemodynamic measurements were made using transpulmonary thermodilution and arterial pulse contour analysis. At 7 days, the difference in change of the primary endpoint of cardiac output between the liraglutide group and control group was +1.1 1/min (95% CI +0.1 to +2.2; P < 0.001). Stroke volume was significantly higher in the liraglutide group compared with the control group (difference: +14.6 ml; P < 0.001). The difference in an increase in the left ventricular contractile index after 7 days of treatment was +210.7 mmHg/s (liraglutide versus control, 95% CI−92.1 to +501.5; P < 0.001). Liraglutide causes favorable changes in markers of inflammation and oxidative stress. Glucagon-like peptide-1 may be associated with improvement in left ventricular function in patients with heart failure. These findings need to be confirmed by larger invasive trials.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.