Research Papers:

Radial artery intima-media thickness regresses after secondary prevention interventions in patients’ post-acute coronary syndrome and is associated with cardiac and kidney biomarkers

Damilola D. Adingupu, Helena U. Westergren, Santosh Dahgam, Ann-Cathrine Jönsson-Rylander, Juuso Blomster, Per Albertsson, Elmir Omerovic, Sara Svedlund and Li-Ming Gan _

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Oncotarget. 2017; 8:53419-53431. https://doi.org/10.18632/oncotarget.18511

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Damilola D. Adingupu1, Helena U. Westergren1,2, Santosh Dahgam1, Ann-Cathrine Jönsson-Rylander1, Juuso Blomster1,2, Per Albertsson4, Elmir Omerovic4, Sara Svedlund2,3 and Li-Ming Gan1,2,4

1AstraZeneca R&D Gothenburg, Mölndal, Sweden

2Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden

3Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden

4Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden

Correspondence to:

Li-Ming Gan, email: li-ming.gan@gu.se

Keywords: atherosclerosis, cardiovascular, intima-media thickness, inflammation, ultrasound

Received: December 28, 2016     Accepted: May 17, 2017     Published: June 16, 2017


Background: Radial artery intima-media thickness (rIMT) measured by ultra-high-resolution ultrasound is associated with increased cardiovascular risk and predicts outcomes. We performed non-invasive high-resolution ultrasound of the radial artery to investigate vascular changes in subjects presenting with acute coronary syndrome (ACS) and who had undergone percutaneous coronary intervention (PCI).

Purpose: In the present work, we aimed to follow rIMT change over time post-acute coronary syndrome as a tool to monitor potential response to intensified medical therapy.

Methods: We examined 256 subjects who underwent PCI due to ACS and healthy controls (n= 39) and we measured a number of biomarkers, which are known to be associated with cardiovascular disease. Images of radial artery were acquired bilaterally in the longitudinal view using a 50 MHz transducer (Vevo 2100 VisualSonics, Inc, Toronto, Ontario, Canada). Carotid IMT (cIMT) and rIMT were measured at <1 month after index PCI followed by a repeated measurement of rIMT at 4 months from the ACS in a sub-set (n=117).

Results: rIMT measured within 1 month post ACS was significantly higher than rIMT after 4 months from ACS, (p < 0.0001), mean ± SD (rIMT right 0.35 ± 0.08; rIMT left 0.37 ± 0.08) vs. (rIMT right 0.29 ± 0.08; rIMT left 0.31 ± 0.09) respectively. There was no statistically significant change in cIMT. In healthy controls there were no changes in rIMT or cIMT overtime. High levels of CX3CL1 and myeloperoxidase measured within one month post ACS are associated with increase of rIMT, r=0.38 (p< 0.0001) and r=0.41 (p< 0.0001) respectively.

Conclusions: rIMT seem to decrease systemically after ACS and is accompanied with corresponding biomarker change. The cause and clinical implications of the observed decrement in rIMT after ACS need further studies.

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