Oncotarget

Clinical Research Papers:

Optimized ROI size on ADC measurements of normal pancreas, pancreatic cancer and mass-forming chronic pancreatitis

Chao Ma, Jing Li, Mbaiaoure Barak Boukar, Panpan Yang, Li Wang, Luguang Chen, Li Su, Jianxun Qu, Shi-Yue Chen, Qiang Hao and Jian-Ping Lu _

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Oncotarget. 2017; 8:99085-99092. https://doi.org/10.18632/oncotarget.18457

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Abstract

Chao Ma1, Jing Li1, Mbaiaoure Barak Boukar1, Panpan Yang1, Li Wang1, Luguang Chen1, Li Su2, Jianxun Qu3, Shi-Yue Chen1, Qiang Hao1 and Jian-Ping Lu1

1Department of Radiology, Changhai Hospital of Shanghai, The Second Military Medical University, Shanghai, China

2School of Pharmacy, Second Military Medical University, Shanghai, China

3GE Healthcare, MR Group, Shanghai, China

Correspondence to:

Jian-Ping Lu, email: [email protected]

Keywords: DWI, apparent diffusion coefficient (ADC), pancreatic cancer, region of interest (ROI), chronic pancreatitis

Received: October 19, 2016     Accepted: May 23, 2017     Published: June 12, 2017

ABSTRACT

Objectives: To investigate the effects of region of interest (ROI) sizes on apparent diffusion coefficient (ADC) measurements for the differentiation of normal pancreas (NP), pancreatic ductal adenocarcinoma (PDAC) and mass-forming chronic pancreatitis (MFCP).

Results: There were no significant differences for the mean ADCs measured by 12 different-size ROIs for MFCP, or PDAC and NP (P = 0.858–1.0). With the increase of ROI size (≥ 55 mm2), ADCs of PDAC were significantly lower than those of NP (all P < 0.05), but there was no difference of the accuracy in ADC for differentiating the two groups only at a ROI size of 214 mm2. When ROI size was above 99 mm2, ADCs of MFCP were significantly lower than those of NP (all P < 0.05). There were no significant differences for any of the mean ADCs measured by 12 different-size ROIs between PDAC and MFCP (P > 0.05).

Materials and Methods: Diffusion-weighted imaging (DWI) was performed on 89 participants: 64 with PDAC, 7 with MFCP, as well as 18 healthy volunteers. ADC maps were created using mono-exponential model. A homemade software was used to measure the mean ADC values of 12 concentric round ROIs (areas: 15, 46, 55, 82, 99, 121, 134, 152, 161, 189, 214, 223, and 245 mm2) for the mass of lesions and the NP tissue.

Conclusions: In ADC measurements, the optimized ROI size is 214 mm2 for the differentiation of PDAC and NP; ROI size of ≥ 99 mm2 is recommended to differentiate between MFCP and NP. ADC was not useful for the differentiation of PDAC and MFCP.


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