Clinical Research Papers:

The effect of intraperitoneal chemotherapy on early pain hyperalgesia in patients following elective laparoscopic transabdominal resection of rectal cancer

Min Liang, Chang-Ying Li, Chun-Guang Ren, Zong-Wang Zhang and Zhi-Jian Fu _

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Oncotarget. 2017; 8:51869-51877. https://doi.org/10.18632/oncotarget.18417

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Min Liang1,2, Chang-Ying Li2, Chun-Guang Ren2, Zong-Wang Zhang2 and Zhi-Jian Fu1

1 Department of Pain Management, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, P.R. China

2 Department of Anesthesiology, Liaocheng People’s Hospital, Liaocheng, Shandong, P.R. China

Correspondence to:

Zhi-Jian Fu, email:

Keywords: chemotherapy; hyperalgesia; lobaplatin; colorectal cancer; sufentanil

Received: April 03, 2017 Accepted: May 02, 2017 Published: June 08, 2017


Background: Chemotherapy has been associated with hyperalgesia. This prospective study was designed to investigate the effect of intraperitoneal chemotherapy with lobaplatin on post-operative pain intensity and sufentanil requirements after laparoscopic transabdominal resection of rectal cancer.

Methods: Eighty subjects (40 subjects treated with intraperitoneal chemotherapy and 40 subjects without chemotherapy treatment) scheduled for laparoscopic transabdominal resection of rectal cancer were included in this study. All subjects received standardized anesthetic and patient-controlled analgesia using sufentanil for 72 h post-surgery, as the only analgesics. Pain intensity scores, cumulative sufentanil requirements and side effects were recorded until 72 h post-surgery.

Results: Following intraperitoneal chemotherapy, patients had a significantly higher total post-operative sufentanil requirement (193 µg vs. 142 µg; P = 0.008), significantly higher verbal rating scale post-surgery pain intensity scores at rest and with coughing (P < 0.05), and a significantly worse functional activity score (P < 0.05) over 72 h, compared with those without intraperitoneal chemotherapy. There were no post-operative differences in the incidence of side-effects (post-operative nausea [P = 0.189], vomiting [P = 0.311], pruritus [P = 0.263], respiratory depression [P = 1.000], and dizziness [P = 0.712]) between the two groups.

Conclusion: Intraperitoneal chemotherapy is associated with significantly increased post-operative sufentanil requirements and pain intensity, suggesting chemotherapy-associated hyperalgesia.

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