Clinical Research Papers:

Prognostic impact and implications of extracapsular lymph node spread in Borrmann type IV gastric cancer

Rui-Zeng Dong _, Jian-Min Guo, Ze-Wei Zhang, Yi-Min Zhou and Ying Su

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Oncotarget. 2017; 8:97593-97601. https://doi.org/10.18632/oncotarget.18400

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Rui-Zeng Dong1, Jian-Min Guo1, Ze-Wei Zhang1, Yi-Min Zhou1 and Ying Su2

1Department of Abdominal Surgery, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China

2Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of China

Correspondence to:

Rui-Zeng Dong, email: [email protected]

Keywords: Borrmann type IV gastric cancer, extracapsular lymph node spread, curative resection, prognosis, metastasis

Received: April 05, 2017     Accepted: May 23, 2017     Published: June 07, 2017


The purpose of this study was to evaluate the relationship between extracapsular lymph node spread (ECS) and clinicopathology and its influence on the prognosis in patients with Borrmann type IV gastric cancer. Between 2002 and 2014, clinical data were reviewed from 486 patients with Borrmann type IV gastric cancer who underwent curative resection. Of the 486 patients, lymph node metastasis was found in 456. ECS was detected in 213 (46.7%) patients with lymph node metastasis. A positive lymph node with ECS was significantly correlated with the N category, lymphatic/venous invasion, tumor location, and TNM stage. For the whole patients, the mean OS was 34.7 months, and the 5-year OS rate was 15.5%. The 5-year OS rate of node-negative patients was 48%, for node-positive patients without ECS 18.7%, and for node-positive patients with ECS 5.7% (P = 0.000). In a multivariate analysis, adjusted for tumor location, lymphatic/venous invasion, body mass index (BMI), and TNM stages, ECS remained an independent prognostic factor. For patients with the same N category and TNM stage, those with ECS still had a worse survival rate. Recurrent sites were confirmed in 367 patients. The most frequent recurrent site was the peritoneum. There was a significant difference between ECS+ (N = 150) and ECS- (N = 142) patients (P = 0.008). Our results suggested that ECS was an independent prognostic value for Borrmann type IV gastric cancer patients with curative resection and a subgroup indicated a significantly worse long-term survival for patients with the same N or TNM stages. ECS+ was an adverse factor for peritoneal metastasis.

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