Research Papers:

Mex3a expression and survival analysis of bladder urothelial carcinoma

Jing-Wen Shi and Ying Huang _

PDF  |  HTML  |  How to cite

Oncotarget. 2017; 8:54764-54774. https://doi.org/10.18632/oncotarget.18399

Metrics: PDF 1747 views  |   HTML 2555 views  |   ?  


Jing-wen Shi1 and Ying Huang1

1Department of Ultrasound, Shengjing Hospital of China Medical University, 110004, Shenyang, China

Correspondence to:

Ying Huang, email: [email protected]

Keywords: mex3a, bladder urothelial carcinoma, overall survival, TCGA, pathology

Abbreviations: BLCA: Bladder Urothelial Carcinoma; TCGA: The Cancer Genome Atlas; OS: overall survival; AJCC: American Joint Committee on Cancer; CIS: carcinoma in situ

Received: April 18, 2017    Accepted: May 27, 2017    Published: June 07, 2017


Objective: Bladder urothelial carcinoma is a common tumor in humans and a multifactorial disease. The gene mex3a is associated with tumor formation and may promote cell proliferation and migration. Therefore, this study aimed to determine the relationship between mex3a and bladder urothelial carcinoma.

Methods: The clinical and RNA sequencing expression data in patients with bladder urothelial carcinoma were downloaded from the The Cancer Genome Atlas data portal. A total of 412 bladder urothelial carcinoma samples were available in the database, for which the clinical information was acquired, of which 412 are RNA sequencing samples with a total of 19 paired samples. Univariate and multivariate Cox analyses and univariate logistic regression analysis were conducted using the software SPSS version 22.0 and P<0.05 was considered statistically significant.

Results: The results of the independent t-test of 19 paired samples indicated that the expression level of mex3a was significantly higher in tumor tissues compared with adjacent normal tissues. Mex3a expression as a categorical dependent variable was not associated with overall survival, and the overall survival of bladder urothelial carcinoma was associated with the group of age, cancer status, lymphatic vascular invasion, pathological stage, pathological size, and pathological lymph metastasis. The multivariable Cox model adjusted for the group of mex3a expression level, age, gender, tumor status, and pathological stage showed that only the age and cancer status groups were associated with the overall survival.

Conclusion: Mex3a expression was not a poor prognostic factor of bladder urothelial carcinoma. Moreover, the expression levels of mex3a in the papillary type of bladder urothelial carcinoma were higher than those of the non-papillary type.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 4.0 License.
PII: 18399