Oncotarget

Research Papers:

Circulating microparticles are prognostic biomarkers in advanced non-small cell lung cancer patients

Chin-Chou Wang, Chia-Cheng Tseng, Huang-Chih Chang, Kuo-Tung Huang, Wen-Feng Fang, Yu-Mu Chen, Cheng-Ta Yang, Chang-Chun Hsiao, Meng-Chih Lin, Chi-Kung Ho and Hon-Kan Yip _

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Oncotarget. 2017; 8:75952-75967. https://doi.org/10.18632/oncotarget.18372

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Abstract

Chin-Chou Wang1,2,3,*, Chia-Cheng Tseng1,4,*, Huang-Chih Chang1,4, Kuo-Tung Huang1,4, Wen-Feng Fang1,3, Yu-Mu Chen1, Cheng-Ta Yang5, Chang-Chun Hsiao4,6,**, Meng-Chih Lin1,**, Chi-Kung Ho2,** and Hon-Kan Yip6,7,8,9,10,**

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan

2Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan

3Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi Campus, Chiayi, Taiwan

4Graduate Institute of Clinical Medical Sciences, Chang Gung University College of Medicine, Kaohsiung, Taiwan

5Department of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan

6Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

7Division of cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

8Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan

9Department of Nursing, Asia University, Taichung, Taiwan

10Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan

*These authors contributed equally to this work and should be considered co-first authors

**These authors contributed equally to this work and should be considered co-correspondence authors

Correspondence to:

Hon-Kan Yip, email: [email protected]

Keywords: advanced non-small cell lung cancer, microparticles, disease control, disease progression

Received: January 09, 2017     Accepted: April 25, 2017     Published: June 06, 2017

ABSTRACT

We investigated whether circulating microparticles (MPs) could serve as prognostic biomarkers in non-small cell lung cancer (NSCLC) patients. We enrolled 25 control subjects and 136 NSCLC patients categorized into disease-progression (DP, n=42) and disease-control (DC, n=94) groups. Flow cytometric analysis showed that levels of four types of circulating microparticles (EDAc-MPs, EDAp-MPs, PDAc-MPs and PDAp-MPs) were higher in the study patients than the control subjects (P < 0.04). DP patients showed poor initially performance status and more non-adenocarcinomas than DC patients. DC patients showed more EGFR mutations and poorer performance to targeted therapy than DP patients (P < 0.01). Three months after therapy, the levels of all four types of circulating MPs were lower in DC than DP patients (P < 0.02), and were comparable to the levels in control subjects. In addition, the levels of circulating MPs after 3 months accurately predicted one-year prognostic outcomes (P < 0.05). This study showed that circulating MPs are valuable prognostic biomarkers in advanced NSCLC patients.


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