Oncotarget

Research Papers:

Increased p16 and p53 protein expression predicts poor prognosis in mucosal melanoma

Hanbin Chen, Yangyang Li, Yin Long, Erjiang Tang, Rongrong Wang, Kate Huang _, Congying Xie and Guorong Chen

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Oncotarget. 2017; 8:53226-53233. https://doi.org/10.18632/oncotarget.18367

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Abstract

Hanbin Chen1,*, Yangyang Li2,*, Yin Long3, Erjiang Tang3, Rongrong Wang2, Kate Huang2,*, Congying Xie1,* and Guorong Chen2,*

1Department of Radiotherapy and Chemotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

2Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

3Center for Translational Medicine, Yangpu Hospital, Tongji University School of Medicine, Yangpu, Shanghai, China

*These authors have contributed equally to this work

Correspondence to:

Kate Huang, email: handyman2002@163.com

Congying Xie, email: wzxiecongying@163.com

Guorong Chen, email: chengr1978@aliyun.com

Key words: p16 protein, p53 protein, mucosal melanoma, prognosis of mucosal melanoma

Received: April 07, 2017    Accepted: May 10, 2017    Published: June 05, 2017

ABSTRACT

Primary mucosal melanoma (MM) is a rare, and aggressive, neoplasm with a poor prognosis. To date, few prognostic markers of MM have been well-defined. The aim of this study is to clarify the prognostic value of p53 and p16 proteins in predicting the clinical outcome of Chinese patients with MM.

A total of 59 MM samples were contained from biopsy specimens, and, expressions of p53 and p16 proteins were assessed by immunohistochemistry. Cox regression analysis was performed to investigate the association of these proteins with the overall survival of MM patients. Increased p16 expression was significantly associated with reduced survival at three years (P=0.039). Increased p53 expression correlates with reduced one-year (P=0.025), and, two-year survival (P=0.037).

Increased p53 and p16 protein expression may be helpful prognostic indicators for the management of these patients.


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