Preclinical evidence of ghrelin as a therapeutic target in epilepsy

Tongtong Ge, Wei Yang, Jie Fan and Bingjin Li _

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Oncotarget. 2017; 8:59929-59939. https://doi.org/10.18632/oncotarget.18349

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Tongtong Ge1,*, Wei Yang1,*, Jie Fan1 and Bingjin Li1

1Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, PR China

*These authors contributed equally to this work

Correspondence to:

Bingjin Li, email: [email protected]

Keywords: ghrelin, epilepsy, hippocampus, memory, neuroprotection

Received: March 08, 2017     Accepted: May 22, 2017     Published: June 02, 2017


Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin’s anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy.

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