Preclinical evidence of ghrelin as a therapeutic target in epilepsy
Metrics: PDF 1198 views | HTML 2398 views | ?
Tongtong Ge1,*, Wei Yang1,*, Jie Fan1 and Bingjin Li1
1Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun 130041, PR China
*These authors contributed equally to this work
Bingjin Li, email: email@example.com
Keywords: ghrelin, epilepsy, hippocampus, memory, neuroprotection
Received: March 08, 2017 Accepted: May 22, 2017 Published: June 02, 2017
Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin’s anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy.
All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.