This article has been corrected. Correction in: Oncotarget. 2017; 8:100957.

Prognostic and diagnostic significance of lncRNAs expression in cervical cancer: a systematic review and meta-analysis

Shuqi Chi, Lina Shen, Teng Hua, Shuangge Liu, Guobing Zhuang, Xiaoxiao Wang, Xing Zhou, Guozhen Wang and Hongbo Wang _

PDF  |  HTML  |  Supplementary Files  |  How to cite  |  Order a Reprint

Oncotarget. 2017; 8:79061-79072. https://doi.org/10.18632/oncotarget.18323

Metrics: PDF 2023 views  |   HTML 1974 views  |   ?  


Shuqi Chi1,*, Lina Shen1,*, Teng Hua1,*, Shuangge Liu1, Guobing Zhuang1, Xiaoxiao Wang1, Xing Zhou1, Guozhen Wang1 and Hongbo Wang1

1 Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

* These authors have contributed equally to this work

Correspondence to:

Hongbo Wang, email:

Keywords: cervical cancer, long noncoding RNA, prognosis, diagnosis, meta-analysis

Received: February 14, 2017 Accepted: April 17, 2017 Published: May 31, 2017


Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in cervical cancer (CC) and presumably serve as diagnostic or prognostic markers. We thus performed a systematic review and meta-analysis to evaluate the clinical values of dysregulated lncRNAs in CC. A literature search was performed using the electronic databases PubMed, Embase, and Web of Science. A total of 22 relevant studies were eligible, including 21 on clinicopathological features, 18 on prognosis, and 4 on diagnosis. For clinicopathological features, HOTAIR expression was positively associated with tumor size (odds ratio [OR]=2.19, 95% confidence interval [CI] 1.42-3.38, P=0.000) and lymph node metastasis (OR=6.04, 95% CI 3.51-10.42, P=0.000). For the prognostic values, up-regulated HOTAIR had an unfavorable impact on overall survival ([OS]; hazard ratio [HR]=1.94, 95%CI 1.17-3.22, P=0.011) and disease-free survival (HR=2.61, 95%CI 1.35-5.05, P=0.004), and high PVT1 expression was correlated with shorter OS (HR=1.66, 95%CI 1.21-2.29, P=0.002). For the diagnostic values, the pooled result showed an area under the curve (AUC) of 0.85, with 85% sensitivity and 81% specificity in discriminating patients with CC from healthy controls. Overall, we conclude that lncRNAs might serve as promising indicators for prognostic and diagnostic evaluation of patients with CC.

Creative Commons License All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
PII: 18323