Research Papers:

Rcan2 and estradiol independently regulate body weight in female mice

Ling-Cui Ding, Qian-Qian Gong, Shi-Wei Li, Xiao-Long Fu, Ye-Cheng Jin, Jian Zhang, Jian-Gang Gao and Xiao-Yang Sun _

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Oncotarget. 2017; 8:48098-48109. https://doi.org/10.18632/oncotarget.18259

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Ling-Cui Ding1, Qian-Qian Gong1, Shi-Wei Li1, Xiao-Long Fu1, Ye-Cheng Jin1, Jian Zhang1, Jian-Gang Gao1 and Xiao-Yang Sun1

1Institute of Developmental Biology, School of Life Science, Shandong University, Jinan, China

Correspondence to:

Xiao-Yang Sun, email: sunxy70@sdu.edu.cn

Keywords: Rcan2, 17β-estradiol, ovariectomy, body weight regulation, obesity

Received: January 05, 2017    Accepted: May 05, 2017    Published: May 29, 2017


Rcan2 increases food intake and plays an important role in the development of age- and diet- induced obesity in male mice. However, in females, wild-type mice grow almost at a similar rate as Rcan2−/− mice on normal chow diet from 6 weeks of age. Here we showed that the ability of Rcan2 to promote weight gain was attenuated by energy expenditure mediated by 17β-estradiol in female mice. Using ovariectomy-operated models, we found that 17β-estradiol deprivation did not alter food intake, but induced more weight gain in wild-type mice than Rcan2−/− mice. If wild-type mice ingested equally as Rcan2−/− mice, in the same ovarian state they exhibited similar weight changes, but the mice in ovariectomized groups were significantly heavier than the ovarian-intact mice, suggesting that body weight is not only regulated by Rcan2, but also by 17β-estradiol. Furthermore, we demonstrated that Rcan2 and 17β-estradiol independently regulated body weight even on high-fat diets. Therefore, our findings indicate that Rcan2 and 17β-estradiol regulate body weight through different mechanisms. Rcan2 increases food intake, whereas 17β-estradiol promotes energy expenditure. These findings provide novel insights into the sexual dimorphism of body weight regulation.

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