miR-34: from bench to bedside
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Massimiliano Agostini1 and Richard A. Knight1
1 Medical Research Council, Toxicology Unit, Leicester University, Leicester, UK.
Massimiliano Agostini, email:
Keywords: microRNA, miR-34 family, cancer, therapy
Received: February 16, 2014 Accepted: March 15, 2014 Published: March 15, 2014
The mir-34 family was originally cloned and characterized in 2007 as a p53 target gene. Almost immediately it became clear that its major role is as a master regulator of tumor suppression. Indeed, when overexpressed, it directly and indirectly represses several oncogenes, resulting in an increase of cancer cell death (including cancer stem cells), and in an inhibition of metastasis. Moreover, its expression is deregulated in several human cancers. In 2013, a miR-34 mimic has become the first microRNA to reach phase 1 clinical trials. Here we review the miR-34 family and their role in tumor biology, and discuss the potential therapeutic applications of miR-34a mimic.
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