Role of LOXL2 in the epithelial-mesenchymal transition and colorectal cancer metastasis
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Pil-Gu Park1,*, Su Ji Jo1,2,*, Min Jung Kim1,3, Hyun Jeong Kim4, Ji Hae Lee5, Cheol Keun Park6, Hyunki Kim6, Kang Young Lee7, Hoguen Kim2,6, Jeon Han Park1, Seung Myung Dong5,8 and Jae Myun Lee1,2
1Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, Republic of Korea
2BK21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea
3Department of Pediatrics, Severance Hospital, Institute of Allergy, Yonsei University College of Medicine, Seoul, Republic of Korea
4Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
5Research Institute, National Cancer Center, Goyang, Republic of Korea
6Department of Pathology, Yonsei University, College of Medicine, Seoul, South Korea
7Department of Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
8IMK Bio-Convergence R&D Center, International Vaccine Institute SNU Research Park, Seoul, Republic of Korea
*These authors contributed equally to this work
Jae Myun Lee, email: [email protected]
Seung Myung Dong, email: [email protected]
Keywords: colorectal cancer, metastasis, LOXL2, epithelial-mesenchymal transition, tissue microarray analysis
Received: March 24, 2017 Accepted: May 11, 2017 Published: May 25, 2017
Colorectal cancer (CRC) is one of the most dangerous types of malignant tumors, and cancer metastasis is a major factor in the failure of CRC therapy. Recently, LOXL2 (lysyl oxidase-like 2) has been shown to represent a regulator of epithelial-mesenchymal transition (EMT) in different cancer types. However, LOXL2 has not been reported to be involved in CRC metastasis. In this study, we demonstrated that LOXL2 expression is strongly correlated with the rate of CRC metastasis, it participates in the regulation of EMT-related molecule expression in CRC cells in vitro, and it is involved in migratory potential alterations. Additionally, tissue microarray analysis of CRC patients showed an increase in the probability of developing CRC distant metastasis and a decrease in the survival rate of patients with high LOXL2 expression. The results obtained in this study indicate that LOXL2 is involved in the development and progression of CRC metastasis, and therefore, its expression levels may represent a useful prognostic marker.
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