Clinical Research Papers:

Tumor necrosis and complete resection has significant impacts on survival in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma

Moo-Kon Song, Joo-Seop Chung, Ho-Young Yhim, Sung-Nam Lim, Seong-Jang Kim, Yeon-Hee Han, Hye-Kyung Shim, Sung-Hoon Jung, Je-Jung Lee and Deok-Hwan Yang _

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Oncotarget. 2017; 8:79337-79346. https://doi.org/10.18632/oncotarget.18107

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Moo-Kon Song1, Joo-Seop Chung2, Ho-Young Yhim3, Sung-Nam Lim4, Seong-Jang Kim5, Yeon-Hee Han6, Hye-Kyung Shim7, Sung-Hoon Jung8, Je-Jung Lee8 and Deok-Hwan Yang8

1 Department of Hemato-Oncology, Hanyang University Hanmaeum Changwon Hospital, Changwon, Korea

2 Department of Hematology-Oncology, Pusan National University Hospital, Busan, Korea

3 Department of Hematology, Chonbuk National University Hospital, Jeonju, Korea

4 Department of Hematology, Busan Haeundae Paik Hospital, Busan, Korea

5 Department of Nuclear Medicine, Pusan National University Hospital, Busan, Korea

6 Department of Nuclear Medicine, Chonbuk National University Hospital, Jeonju, Korea

7 Department of Nuclear Medicine, Busan Haeundae Paik Hospital, Busan, Korea

8 Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea

Correspondence to:

Deok-Hwan Yang, email:

Keywords: extranodal natural killer/T-cell lymphoma, tumor necrosis, complete resection, prognosis

Received: March 31, 2017 Accepted: May 10, 2017 Published: May 23, 2017


Tumor necrosis (TN) is associated with worse prognosis in several solid cancers. Whether TN predicts poor outcome in natural killer cell / T cell lymphoma (NKTCL) is unclear. We investigated the clinical impact of TN on survival and other novel prognostic parameters in upper aero-digestive tract (UAT) NKTCL of 100 patients with limited stage. TN was significantly associated with poor performance status (p = 0.049), high Korean Prognostic Index score (p = 0.024), high C-reactive protein/albumin ratio (p = 0.003), higher maximum standard uptake value on positron emission tomography/computed tomography (PET/CT) (p = 0.008) and higher metabolic tumor volume (MTV) on PET/CT (p < 0.001). In univariate and multivariate analyses, progression-free survival and overall survival were independently associated with High MTV status (p = 0.001, p = 0.032), TN (p = 0.018, p = 0.009), local tumor invasiveness (p = 0.007, p = 0.035), complete resection (p = 0.020, p = 0.028) and regional lymph node involvement (p < 0.001, p < 0.001). TN and complete resection are concluded to be novel independent prognostic factors in patients with UAT NKTCL.

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