Oncotarget

Research Papers:

AGO2 involves the malignant phenotypes and FAK/PI3K/AKT signaling pathway in hypopharyngeal-derived FaDu cells

Yanhui Zhang, Baoxin Wang, Xinwei Chen, Weidong Li and Pin Dong _

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Oncotarget. 2017; 8:54735-54746. https://doi.org/10.18632/oncotarget.18047

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Abstract

Yanhui Zhang1, Baoxin Wang2, Xinwei Chen2, Weidong Li3 and Pin Dong2

1Department of Otolaryngology Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

2Department of Otolaryngology Head and Neck Surgery, Shanghai General Hospital, Shanghai, China

3Bio-X Institutes, Key Laboratory for The Genetics of Development and Neuropsychiatric Disorders (Ministry of Education), Shanghai Key Laboratory of Psychotic Disorders, and Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China

Correspondence to:

Pin Dong, email: [email protected]

Weidong Li, email: [email protected]

Keywords: AGO2, hypopharyngeal cancer, cell proliferation, FAK/PI3K/AKT signaling pathway

Received: November 16, 2016     Accepted: April 03, 2017     Published: May 22, 2017

ABSTRACT

Argonaute 2 (AGO2) protein is usually overexpressed in various head and neck squamous cell carcinoma. However, the precise molecular mechanisms of AGO2 in hypopharyngeal cancer have not yet been clearly understood. Here we found the AGO2 expression in hypopharyngeal cancer tissues were generally higher comparing with that of the corresponding adjacent noncancerous epithelium tissues, and these were associated with the more aggressive clinicopathologic features and the poor clinical outcomes. Stable knockdown of AGO2 protein retarded cell proliferation, migration, invasion, arrested cell cycle and induced apoptosis. Meanwhile the knockdown also inhibited the FAK/PI3K/AKT signaling pathway in hypopharyngeal-derived FaDu cells. These findings suggested that AGO2 gene might act as an oncogene which contributed to the tumorigenesis and progression, and has potential values for molecular diagnosis, clinical therapies and prognosis evaluation in hypopharyngeal cancer.


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PII: 18047