Oncotarget

Research Papers:

Pre-operative to post-operative serum carcinoembryonic antigen ratio is a prognostic indicator in colorectal cancer

Zhenqiang Sun _, Fuqi Wang, Quanbo Zhou, Shuaixi Yang, Xiantao Sun, Guixian Wang, Zhen Li, Zhiyong Zhang, Junmin Song, Jinbo Liu and Weitang Yuan

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Oncotarget. 2017; 8:54672-54682. https://doi.org/10.18632/oncotarget.17931

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Abstract

Zhenqiang Sun1,*, Fuqi Wang1,*, Quanbo Zhou1, Shuaixi Yang1, Xiantao Sun1, Guixian Wang1, Zhen Li1, Zhiyong Zhang1, Junmin Song1, Jinbo Liu1 and Weitang Yuan1

1Department of Anorectal Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

*Co-first authors

Correspondence to:

Zhenqiang Sun, email: [email protected]

Weitang Yuan, email: [email protected]

Jinbo Liu, email: [email protected]

Keywords: colorectal cancer, CEA, tumor marker, prognosis

Received: April 15, 2017     Accepted: May 05, 2017     Published: May 17, 2017

ABSTRACT

We explored the prognostic significance of the pre-operative-to-post-operative serum carcinoembryonic antigen (pre-post-CEA) ratio in colorectal cancer (CRC). We detected pre- and post-operative CEA levels in 2035 CRC patients surgically treated at First Affiliated Hospital of Zhengzhou University between June 2001 and June 2011. Univariate analysis revealed the pre-post-CEA ratio is associated with distant metastasis and degree of tumor differentiation (both P < 0.05). Multivariate analysis showed that the pre-post-CEA ratio is associated with lymphatic and distant metastasis, tumor-node-metastasis (TNM) stage and degree of tumor differentiation (all P < 0.01). The pre-CEA levels, pre-post-CEA ratios, distant metastasis, TNM stage and degree of tumor differentiation were all associated with 5-yr overall survival (all P < 0.05) based on multivariate analysis. Consequently, pre-CEA levels, pre-post-CEA ratios, distant metastasis and TNM stage are independent risk factors for CRC. We have thus demonstrated that the pre-post-CEA ratio is a prognostic indicator for CRC patients.


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