Oncotarget

Research Papers:

Relationship between expression of PD-L1 and tumor angiogenesis, proliferation, and invasion in glioma

Song Xue, Man Hu, Peifeng Li, Ji Ma, Li Xie, Feifei Teng, Yufang Zhu, Bingjie Fan, Dianbin Mu _ and Jinming Yu

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Oncotarget. 2017; 8:49702-49712. https://doi.org/10.18632/oncotarget.17922

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Abstract

Song Xue1,2,3,*, Man Hu2,3,4,*, Peifeng Li5, Ji Ma4,6, Li Xie4,7, Feifei Teng2,3,4, Yufang Zhu4,8, Bingjie Fan2,3,4, Dianbin Mu4,9 and Jinming Yu2,3,4

1School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China

2Shandong Academy of Medical Sciences, Jinan, Shandong, China

3Department of Radiation Oncology, Shandong Province Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China

4Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, China

5Department of Pathology, General Hospital of Jinan Military Command, Jinan, Shandong, China

6Department of Medicine, Shandong Cancer Hospital and Institute, Jinan, Shandong, China

7Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China

8Department of Neurosurgery, Shandong Cancer Hospital and Institute, Jinan, Shandong, China

9Department of Pathology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China

*These authors contributed equally to this work

Correspondence to:

Dianbin Mu, email: mudbin@163.com

Jinming Yu, email: sdyujinming@163.com

Keywords: PD-L1, angiogenesis, proliferation, invasion, glioma

Received: January 26, 2017     Accepted: May 01, 2017     Published: May 17, 2017

ABSTRACT

Programmed death ligand 1 (PD-L1) is highly expressed in many cancers. We investigated the expression of PD-L1 and its relationship with vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 and KI-67 expression in 64 patients with primary glioma. The expression rate of PD-L1 in glioma patients was 78.12%. PD-L1 levels correlated with the tumor grade (p = 0.013), VEGF status (p = 0.002) and KI-67 status (p = 0.002). In addition, PD-L1 levels correlated positively with VEGF (r = 0.314, p = 0.011) and KI-67 (r = 0.391, p = 0.001) levels when the data were treated as continuous variables. This is the first report suggesting that PD-L1 is important for glioma angiogenesis and proliferation. Thus, further research should be conducted to assess the combination of targeted VEGF therapy and anti-PD-L1 immunotherapy for the treatment of glioma.


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