Oncotarget

Research Papers:

Abnormal amplitude of low-frequency fluctuations associated with rapid-eye movement in chronic primary insomnia patients

Qian Ran, Jia Chen, Chuan Li, Li Wen, Faguo Yue, Tongsheng Shu, Jianxun Mi, Guangxian Wang, Lei Zhang, Dong Gao and Dong Zhang _

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Oncotarget. 2017; 8:84877-84888. https://doi.org/10.18632/oncotarget.17921

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Abstract

Qian Ran1,*, Jia Chen1,*, Chuan Li1, Li Wen1, Faguo Yue2, Tongsheng Shu1, Jianxun Mi3, Guangxian Wang1, Lei Zhang1, Dong Gao2 and Dong Zhang1

1Department of Radiology, The Second Affiliated Hospital of The Third Military Medical University, Sha Pingba, Chongqing 400037, China

2Department of Sleep and Psychology, Institute of Surgery Research, The Third Affiliated Hospital of The Third Military Medical University, Da Ping, Chongqing 400042, China

3College of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing 400065, China

*First authors

Correspondence to:

Dong Zhang, email: [email protected]

Dong Gao, email: [email protected]

Keywords: insomnia, REM, ALFF, resting-state fMRI, PSG

Received: March 24, 2017     Accepted: May 03, 2017     Published: May 17, 2017

ABSTRACT

Purpose: Chronic primary insomnia (CPI) is the most prevalent sleep disorder worldwide. CPI manifests as difficulties in sleep onset, maintaining sleep, prolonged sleep latency, and daytime impairment and is often accompanied by cognitive problems such as poor academic performance, poor attention, and decreased memory. The most popular explanation of insomnia is hyperarousal or increased activities of neurons. Rapid eye movement (REM) sleep detected by polysomnography (PSG) exhibits a positive relationship with brain homeostasis and can be helpful for optimally preparing an organism for emotional and social function. Limited work has been performed to explore brain function of insomnia patients in combination with PSG analysis.

Results: We observed increased ALFF within areas related to hyperarousal such as the midbrain and bilateral extra-nucleus, whereas decreased ALFF was observed within areas associated with memory and attention involving the parietal and occipital lobule and others. Furthermore, the altered ALFF was associated with the duration of insomnia, sleep efficiency, duration of REM, latency of RME and ratio of REM.

Materials and Methods: In this study, we recruited twenty-five CPI patients and twenty-five normal sleep (NS) volunteers as a control group to investigate the amplitude of low-frequency fluctuations (ALFF) and the correlation between those altered ALFF regions through resting-state fMRI and PSG data.

Conclusions: These findings suggest that hyperarousal reflected by ALFF abnormality within brain areas related to cognition and emotion in insomnia associated with REM sleep.


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