Oncotarget

Research Papers:

Renal cell carcinoma histological subtype distribution differs by age, gender, and tumor size in coastal Chinese patients

Junlong Wu, Peipei Zhang, Guiming Zhang, Hongkai Wang, Weijie Gu, Bo Dai, Hailiang Zhang, Guohai Shi, Yijun Shen, Yiping Zhu, Yao Zhu and Dingwei Ye _

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Oncotarget. 2017; 8:71797-71804. https://doi.org/10.18632/oncotarget.17894

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Abstract

Junlong Wu1,3,*, Peipei Zhang2,3,*, Guiming Zhang4,*, Hongkai Wang1,3, Weijie Gu1,3, Bo Dai1,3, Hailiang Zhang1,3, Guohai Shi1,3, Yijun Shen1,3, Yiping Zhu1,3, Yao Zhu1,3 and Dingwei Ye1,3

1Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China

2Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

4Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, China

*These authors contributed equally to this work

Correspondence to:

Dingwei Ye email: [email protected]

Yao Zhu email: [email protected]

Keywords: renal cell carcinoma, histological subtype, distribution, Chinese, SEER

Received: October 12, 2016     Accepted: April 30, 2017     Published: May 16, 2017

ABSTRACT

The distribution pattern of renal cell carcinoma (RCC) histological subtypes according to age, gender and tumor size has not been well illustrated in RCC patients living in fast-developing regions of China. We recruited 2941 patients with clear cell renal cell carcinoma (ccRCC), papillary renal cell carcinoma (PCC) or chromophobe from two hospitals in coastal China (2004−2012) consecutively and draw 538 American Chinese RCC patients’ data with time matched from the Surveillance, Epidemiology, and End Results database. We found that compared with ccRCC patients, chromophobe patients were more likely to be female (OR: 2.538, 95% CI: 1.923−3.350), younger (OR for 51−60 years old: 0.686; OR for over 60 years old: 0.478; reference: age < 50) and to have a larger maximal diameter (Dmax) (OR for Dmax > 7 cm: 1.883; reference: Dmax ≤ 4 cm). Besides, in comparison with coastal Chinese patients, American Chinese individuals had lower Fuhrman grades (P < 0.001) and had an onset age 10 years delay. In conclusion, we were the first to observe marked gender, age and tumor size differences in the proportional subtype distribution of RCCs in coastal Chinese patients, and also the first to compare coastal Chinese with American Chinese data.


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