Research Papers:

Evaluation of cumulative prognostic score based on pretreatment plasma fibrinogen and serum albumin levels in patients with newly diagnosed high-grade gliomas

Zhen-Qiang He, Hao Duan, Chao Ke, Xiang-Heng Zhang, Cheng-Cheng Guo, Fuad Al-Nahari, Ji Zhang, Zheng-He Chen, Yin-Sheng Chen, Zhi-Gang Liu, Jian Wang, Zhong-Ping Chen, Xiao-Bing Jiang and Yong-Gao Mou _

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Oncotarget. 2017; 8:49605-49614. https://doi.org/10.18632/oncotarget.17849

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Zhen-Qiang He1,*, Hao Duan1,*, Chao Ke1, Xiang-Heng Zhang1, Cheng-Cheng Guo1, Fuad Al-Nahari1, Ji Zhang1, Zheng-He Chen1, Yin-Sheng Chen1, Zhi-Gang Liu2, Jian Wang1, Zhong-Ping Chen1, Xiao-Bing Jiang1 and Yong-Gao Mou1

1Department of Neurosurgery/Neuro-Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China

2Key Laboratory of Translational Radiation Oncology, Hunan Province, Department of Radiation Oncology, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, 410013, China

*These authors contributed equally to this work

Correspondence to:

Yong-Gao Mou, email: [email protected]

Xiao-Bing Jiang, email: [email protected]

Keywords: high-grade gliomas, fibrinogen, albumin, cumulative score, prognosis

Received: March 10, 2017     Accepted: April 29, 2017     Published: May 13, 2017


This retrospective study was designed to determine the prognostic value of a cumulative score (FA score) based on pretreatment plasma fibrinogen and serum albumin levels for 326 patients newly diagnosed high-grade glioma (HGG). Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cut-off values. Univariate and multivariate analysis were performed to evaluate the independent prognostic value of the FA scores associated with overall survival (OS) and progression-free survival (PFS). The optimal cut-off values were 2.815 g/L for fibrinogen and 43.65 g/L for albumin. PFS and OS were significantly worse for patients with higher FA scores. Patients with elevated fibrinogen level and decreased albumin levels had 3.00-fold higher risk of tumor progression and had a 3.23-fold higher risk of death compared with those with normal values. Multivariate analysis demonstrated FA score was an independent predictive factor for PFS and OS. Moreover, PFS and OS were better for the patients with lower FA score, either in patients with grade III or IV gliomas. These findings indicated that the pretreatment FA score could serve as a simple and noninvasive marker to predict the prognosis of patients with HGG.

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