Oncotarget

Research Papers:

PDGFRA, HSD17B4 and HMGB2 are potential therapeutic targets in polycystic ovarian syndrome and breast cancer

Huiyu Xu, Yong Han, Jiaying Lou, Hongxian Zhang, Yue Zhao, Balázs Győrffy and Rong Li _

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Oncotarget. 2017; 8:69520-69526. https://doi.org/10.18632/oncotarget.17846

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Abstract

Huiyu Xu1,*, Yong Han2,*, Jiaying Lou3, Hongxian Zhang4, Yue Zhao1, Balázs Győrffy5,6 and Rong Li1

1Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, P.R. China

2Department of Pathology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang Province, P.R. China

3Department of Clinical Laboratory, Renmin Hospital of Xiaoshan District, Hangzhou, Zhejiang Province, P.R. China

4Department of Urology, Peking University Third Hospital, Beijing, P.R. China

5Momentum Cancer Biomarker Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary

6Second Department of Pediatrics, Semmelweis University, Budapest, Hungary

*These authors have contributed equally to this work

Correspondence to:

Rong Li, email: [email protected]

Keywords: PCOS, obese, insulin-resistant, muscle, breast cancer

Received: June 30, 2016     Accepted: April 26, 2017     Published: May 13, 2017

ABSTRACT

To explore the key genes associated with both PCOS and breast cancer, we overlapped the synchronously differently expressed genes in two obese insulin-resistant GEO datasets in muscle tissue and genes exert essential roles in breast cancer prognosis together base on the following reasons: (1) Androgens excess is believed to contribute to the onset of both PCOS and breast cancer. (2) PCOS is usually complicated with metabolic symptoms, such as obesity and insulin-resistance. (3) Muscle is the main place where energy metabolism and material metabolism take place. Consequently, 53 genes were found, functionally enriched in pathways such as pyruvate metabolism, muscle system process and development of primary male sexual characteristics etc. We further lay our eyes on genes correlated with male sexual characteristics, which may be involved in the onset of both PCOS and breast cancer. Three genes were indicated to be associated with this process, including hydroxysteroid (17-beta) dehydrogenase 4/HSD17B4, platelet-derived growth factor receptor, alpha polypeptide/PDGFRA and high-mobility group box 2/HMGB2. Gene-drug interaction network about the three genes were then constructed. Drugs or chemicals that contribute to correcting the disorder of lipid metabolism were detected to restore the abnormal expression of the three genes in PCOS, such as simvastatin, bezafibrate, fenofibrate et al, which provide further choices for managing patients with PCOS.


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