Microbiota-gut-brain axis and the central nervous system

Xiqun Zhu, Yong Han, Jing Du, Renzhong Liu, Ketao Jin and Wei Yi _

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Oncotarget. 2017; 8:53829-53838. https://doi.org/10.18632/oncotarget.17754

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Xiqun Zhu1,*, Yong Han2,*, Jing Du3,*, Renzhong Liu1, Ketao Jin4 and Wei Yi1

1Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, P.R. China

2Clinical Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, P.R. China

3Department of Gastroenterology, Zhejiang Provincial People’s Hospital, Hangzhou, Zhejiang, P.R. China

4Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang, P.R. China

*These authors contributed equally to this work

Correspondence to:

Wei Yi, email: [email protected]

Ketao Jin, email: [email protected]

Keywords: gut microorganism, microbiota-gut-brain axis, central nervous system, disorders

Received: April 19, 2017     Accepted: April 26, 2017     Published: May 10, 2017


The gut and brain form the gut-brain axis through bidirectional nervous, endocrine, and immune communications. Changes in one of the organs will affect the other organs. Disorders in the composition and quantity of gut microorganisms can affect both the enteric nervous system and the central nervous system (CNS), thereby indicating the existence of a microbiota-gut-brain axis. Due to the intricate interactions between the gut and the brain, gut symbiotic microorganisms are closely associated with various CNS diseases, such as Parkinson's disease, Alzheimer's disease, schizophrenia, and multiple sclerosis. In this paper, we will review the latest advances of studies on the correlation between gut microorganisms and CNS functions & diseases.

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